| Objective To evaluate the value of IL-33 and CA19-9 in the diagnosis of pancreatic cancer and to provide reference for the early diagnosis, clinical prognosis evaluation and pathological degree evaluation of pancreatic cancer.Methods(1) Selected 134 cases were treated by CT in patients with suspected pancreatic cancer as the research object. Collect all patients with CT scan in the diagnosis of data, CA19-9, IL-33 check data, undertake the following analysis:(I) will CA19-9 and IL-33 on pancreatic cancer diagnosis and image diagnosis results were compared, the evaluation of CA19-9 and IL-33 of image science suspected the accurate rate of pancreatic cancer.(II) compare the results of CA19-9 and IL-33 in the diagnosis of pancreatic cancer and the results of pathological examination. The accuracy of CA19-9 and IL-33 in the diagnosis of pancreatic cancer was investigated.(2) 50 cases patients with pancreatic cancer, 70 patients with pancreatitis and 50 healthy people were selected as the research subjects. The baseline data of the 3 groups were consistent. There was no significant difference between the two groups(P>0.05). The following studies were carried out:(I) The differences in the levels of IL-33 and CA19-9 in the peripheral blood of the three groups were investigated.(II) To evaluate the sensitivity, specificity and accuracy of IL-33 and CA19-9 in the diagnosis of pancreatic cancer.(III) Study of the levels of IL-33 and CA19-9 in peripheral blood of patients with pancreatic carcinoma of different pathological stages.Results(1) 134 cases suspected patients examined by CT, were diagnosed by pathological examination of 114 cases of pancreatic cancer(85.07%), 20 cases were excluded in patients with pancreatic cancer(14.93%). The pathological results diagnosed with pancreatic cancer in 114 cases, 88 cases(77.19%) in the serum CA19-9 level in patients with abnormal patients, 26 cases of patients with normal CA19-9 level(22.81%). CT examination showed 134 cases of suspected pancreatic cancer patients, CA19-9 levels were normal in 43 cases(32.09%), 26 cases(60.47%) were diagnosed with pancreatic cancer, 17 cases of pancreatic cancer excluded(39.53%). CT examination showed 134 cases of patients with suspected pancreatic cancer, abnormal high levels of CA19-9 in 91 patients(67.91%), the pathological diagnosis of 88 cases of pancreatic cancer(95.60%), 3 cases of pancreatic cancer excluded(4.40%). In 114 patients with pathologically confirmed pancreatic cancer, 81 cases of patients with abnormal increase of IL-33(71.05%), 33 cases(28.95%) patients with IL-33 level in peripheral blood in the normal range. CT examination results in 134 cases of suspected pancreatic cancer, IL-33 levels were normal in 49 cases(36.57%), 35 cases(71.43%) were diagnosed as pancreatic cancer, 14 cases of pancreatic cancer were excluded(28.57%). In 134 patients with suspected pancreatic cancer, 85 cases(63.43%) were diagnosed as pancreatic cancer by pathological examination, 79 cases(92.94%) were diagnosed as pancreatic cancer, and 6 cases(7.06%) were excluded from pancreatic cancer.(2) The level of CA199 divided in to three concentration node, such as 37U/ml, 100U/ml and 1000U/ml, the diagnosis result of pancreatic cancer was compared with pathological results. The results showed, the diagnosis accuracy of pancreatic cancer in three different concentration node were 96.70%,97.40% and 95.12%. The level of IL-33 divided into three concentration gradient as 50pg/ml, 100pg/ml, 300pg/ml, and more than three concentration node, the results showed the diagnosis accuracy of pancreatic cancer in three different concentration node were 92.94%、95.77% and 94.87%.(3) The levels of IL-33 and CA19-9 in pancreatic cancer and pancreatitis group were higher than those in the normal group, and the difference was statistically significant(P<0.05). The level of CA19-9 in pancreatic cancer group was higher than that in pancreatitis group, the difference was statistically significant(P<0.05), but there was no statistical difference between the two groups(P>0.05)(IL-33). The diagnostic sensitivity, specificity and accuracy of CA19-9 for pancreatic cancer were 92.63%, 70% and 83.87%, respectively. The diagnostic sensitivity, specificity and accuracy of IL-33 for pancreatic cancer were 77.83%, 59.84% and 71.46%, respectively. The diagnostic sensitivity, specificity and accuracy were 96.84%, 66.67% and 85.16% in the combined application of the two. There were significant differences in IL-33 and CA19-9 levels in peripheral blood of patients with pancreatic cancer in different pathological stages, and the levels of IL-33 and CA19-9 increased with the increase of pathological grade.Conclusion IL-33 and CA19-9 have a good diagnostic value for imaging abnormalities of pancreatic cancer patients, and can be used as an important tool to correct imaging diagnosis. The difference of IL-33 and CA19-9 levels in acute pancreatitis, pancreatic cancer and normal human and peripheral blood has statistical significance, which has good application value for the diagnosis of pancreatic cancer. There were significant differences in IL-33 and CA19-9 levels in peripheral blood of patients with pancreatic cancer with different pathological stages. Results suggested that IL-33 and CA199 could be used for the evaluation of pancreatic cancer pathological degree. |
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