Association Of Interieukin-6 Gene Polymorphisms With End Stage Renal Disease:a Mete Analysis

Objective:To evaluate the association between interleukin-6 (IL-6) -174G/C,-634C/G polymorphism and end-stage renal disease (ESRD) by Meta-analysis.Methods:Case-control studies on the association between interleukin-6 gene polymorphism and ESRD risk were retrieved by computer from Pubmed, Cochrane library, Embase, CNKI, CBM database from their establishment to Jan,2016. According to the inclusion and exclusion criteria, the methodological quality of the included studies were evaluated, and the data were extracted. The Meta analysis was conducted using Revman5.3 and Stata12.0 software.Results:A total of 9 publications with 9 case-control studies were identified, including 7 eligible studies on-174G/C sites and 4 studies on-634C/G sites. The overall estimates showed that the IL-6-174G/C polymorphism had no statistically association with a increased risk of ESRD [(C vs G):P=0.31; (CC+GC vs GG):P=0.45; (CC vs GG+GC):P=0.16; (CC vs GG): P=0.17; (GC vs GG):P=0.59]. In the subgroup analyses based on ethnicity, no significant association was found between IL-6-174G/C polymorphism with ESRD in either Caucasian or Asian. Overall, the dominant model, homozygous model and heterozygous model of the IL-6-634C/G gene polymorphism had statistically correlations to ESRD risk [(GG+GC vs CC):OR=2.75,95%CI (1.84,4.10), P<0.01; (GG vs CC):OR=3.09,95%CI (1.65,5.76), P<0.01; (GC vs CC):OR=2.45,95%CI (1.56,3.86), P<0.01], whereas both the allele (G vs C) and recessive model(GG vs GC+CC) did not show the relations with ESRD (P=0.11, P=0.20). In the subgroup analyses on ethnicity, the significantly increased risk of ESRD was associated with IL-6-634C/G gene polymorphism in the dominant model, homozygous and heterozygous model of (all P<0.05), but the allele (G vs C) and recessive model(GG vs GC+CC) did not show the relations with ESRD in Caucasian population (all P>0.05)Conclusion:IL-6-174G/C polymorphisms may not be the risk factor for ESRD. The dominant model, homozygous model and heterozygous model of IL-6-634C/G gene polymorphism may be associated with the ESRD risk in overall population and Caucasian.