Interleukin-10Promoter1082A/G Polymorphism Sin And Autoimmune Disease Susceptibility:a Meta-Analysis

Objectives:A meta-analysis to investigate potential correlations between interleukin-10(IL-10) gene promoter1082A/G polymorphisms and susceptibility of autoimmune diseases.Methods:Software comparison and analysis of gene models from twenty scientific publications to calculate overall odds ratio [OR] with95%confidence interval [95%CI]. Comparison and analysis of genotype for promoter polymorphisms included data from a total of3551autoimmune disease patients and4721healthy control patients, who were all in the oriental population. Analysis of oriental patients were subgrouped based on four autoimmune diseases including:systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), diabetes mellitus type I (T1DM), and inflammatory bowel disease (IBD) which includes Crohn’s disease (CD) and ulcerative colitis (UC).Results:The distribution of genotypes varied among the autoimmune diseases; genetic analysis compared four genotypes including:AA vs GG [OR=0.40,(95%CI)=0.25-0.64]; GA vs GG [OR=0.44,(95%CI)=0.28-0.69]; AA/AG vs GG [OR=0.42,(95%CI)=0.27-0.65]; AA vs GA/GG [OR=0.79,(95%CI)=0.63-1.00]. Finding suggested substantial correlation between distribution of IL-10gene promoter1082A/G genotype and reduced susceptibility of specific autoimmune diseases including lupus erythematosus (SLE), rheumatoid arthritis (RA), but no obvious correlation were observed with diabetes mellitus type I (T1DM), and inflammatory bowel disease (IBD). IL-10gene promoter1082A/G polymorphism showed considerable association with reduced susceptibility of systemic lupus erythematosus (SLE) in patients, based on genotype analysis:homozygous comparison of AA vs GG(P=0.01), heterozygous comparison of GA vs GG (P=0.04), and dominant gene model of AA/AG vs GG (P=0.02). IL-10gene promoter1082A/G polymorphism genotype analysis also demonstrated relationship with decreasing susceptibility of rheumatoid arthritis (RA) in patients, with genotypic comparison of AA vs GA/GG (P=0.02). No significant correlations were found between IL-10gene promoter1082A/G polymorphism in patients with either diabetes mellitus type I (T1DM) or inflammatory bowel disease (IBD). Conclusions:IL-10gene promoter1082A/G is associated with susceptibility to autoimmune disease in Oriental populations.