The Clinical Effect Of Extracorporeal Shock Wave Combined With Arthroscopic Surgery On Knee Osteoarthritis And It’s Effect On The Inflammatory Factors In Joint Fluid

Objucteve:To investigate the clinical effect and mechanism of extracorporeal shock wave combined with arthroscopic surgery in the treatment of knee osteoarthritis in early and middle stage.Methods:63 cases of knee osteoarthritis were divided into A, B, C three groups, group A were treated with extracorporeal shock wave therapy, group B underwent arthroscopic surgery, C group underwent arthroscopic surgery combined with extracorporeal shock wave. The limb pain visual analogue score(VAS) and the Western Ontario and McMaster Universities(WOMAC) osteoarthritis index was used to evaluate the clinical effect respectively before treatment and after treatment in the 2,4,12, and 24 weeks. Also, the contents of IL-1β, TNF-a and NO in the joint fluid of the three groups were detected respectively at the same time.Result:The VAS score and WOMAC score of three groups of patients in the 2,4,12, and 24 weeks after treatment were significantly lower than them before treatment, the VAS score and WOMAC score of group C were significantly lower than them of group A and group B(P<0.05), there was no significant difference between group A and group B(P>0.05). The contents of IL-1β, TNF-α and NO in the joint fluid of the three groups in the 2,4, and 12 weeks after treatment were significantly lower than the contents of each index before treatment, the contents of each index of group C were significantly lower than them of the group A and group B(P<0.05), there was no significant difference between group A and group B (P> 0.05). In 24 weeks after treatment, the contents of each index of group C were significantly lower than them before treatment and lower than them of group A and group B at the same time, and the contents of each index in the joint fluid of group A and group B had no significant difference compared with them before treatment(P>0.05).Conclusion:The contents of IL-1β, TNF-α and NO in the joint fluid of patients with knee osteoarthritis in early and middle stage can be reduced effectively by extracorporeal shock wave combined with arthroscopic surgery, thus relieving pain, improving joint function and delaying the progression of the osteoarthritis.