| Objective:Firstly to investigate the influence of female BMI on ART pregnancy outcome, and further to research on the effect of normal BMI with abdominal obesity and dyslipidemia metabolism on clinical outcome of IVF/ICSI, in order to provide some clinical ideas for improving the pregnancy rate of ART.Methods:Choose a total of 220 cases as the research object who were under going the first IVF/ICSI treatment in Reproductive Medicine Research Center of the First Affiliated Hospital of Guangxi Medical University from September 2015 to December 2015.Firstly all of the research objects can be divided into three groups according to BMI based on Chinese BMI classification: low BMI group (group A), normal BMI group (group B), high BMI group (group C). Then the normal BMI group (group B) according to abdominal obesity and dyslipidemia standard was divided into two groups, normal size group(group B1) and abdominal obesity group(group B2), blood lipid in normal group(group BI) and hyperlipidemia group(group BII), comparing the general information, treatment related indicators and clinical outcome to each group.Results:â‘ There was no significant difference in BMI groups(P>0.05) between the general situation and the treatment process related indicators. Biochemical pregnancy rate, embryo implantation rate, clinical pregnancy rate of group B were higher than that of group A and C, but the difference was not statistically significant (P>0.05). Early miscarriage rate of group C was higher than that of group A and B, but the difference was not statistically significant (P>0.05).â‘¡The level of serum total testosterone in group B2 was higher than that of in group B1, and the difference was statistically significant (P<0.05). Other general conditions are not statistically significant (P>0.05);The endometrial thickness in group B1 and B2 had significant difference (P<0.05),and the good quality embryo rate group B1 is higher than group B2, and the difference is statistically significant(P<0.05). Other treatment process related indicators were not statistically significant (P>0.05). There was no significant difference between the two groups (P>0.05) in cycle cancellation rate. Biochemical pregnancy rate, embryo implantation rate and clinical pregnancy rate in group B1 is higher than group B2,and the difference was statistically significant(P<0.05).â‘¢group Bâ… and Bâ…¡ generally had no significant difference (P>0.05) in Clinical data; the Gn dose in group Bâ…¡ was obviously higher than that of group Bâ… with significant difference(P<0.05), number of retrieved oocytes, fertilized oocytes, and the number of embryos, good quality embryo rate are higher in group Bâ… than group Bâ…¡, the difference is statistically significant (P<0.05),There were no significant differences in other treatments (P>0.05); There was no significant difference in the rate of embryo implantation rate between the two groups (P>0.05), biochemical pregnancy rate, clinical pregnancy rate are higher in group Bâ… than group Bâ…¡, the difference was statistically significant(P<0.05).Conclusion:â‘ BMI with a higher or lower standard has a certain negative effect on the clinical outcome of ART, but it still needs to expand the sample size for further study.â‘¡Even if the patient with normal BMI, it appears to abdominal obesity may still have negative effects of pregnancy outcome on the biochemical pregnancy rates, embryo implantation rate, clinical pregnancy rate in IVF/ICSI treatment.â‘¢The patients combined with dyslipidemia in normal BMI may required more doses of gonadotrophin, reduce the number of collected oocytes, fertilized oocytes, the number of embryos and high qualified embryo rate,having an adverse impact on biochemical pregnancy rate, clinical pregnancy rate in IVF/ICSI treatment. |
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