Study On The Correlation Among Birth Condition And Glucose And Lipid Metabolism Of Newborns

Objective:Based on the hypothesis of "the developmental origin of health and disease", to analyze the basic situation of birth conditions and glucose and lipid metabolism of newborns,and explore the correlation among them. In order to lay a primary foundation for further exploring the relationship between birth condition,glucose and lipid metabolism of early life, childhood growth and glucose and lipid metabolism and adult obesity, diabetes, cardiovascular disease and so on.Methods:Subjects included all newborns from Jinhua maternity and child care hospital from Oct 2013 to Oct 2015. Then collecting birth condition and umbilical cord glucose and lipid metabolism data of these samples for statistical analysis. All data was recorded by Epidata 3.1, using SPSS20.0 for statistical analysis. Statistical description, t test, single factor variance analysis and LSD test, Pearson correlation and Spearman correlation and multiple linear regression were used for statistical analysis, a=0.05 as the test of significant standards.Results:1. In all 3665 subjects,male was a total of 1989 cases(54.3%), female 1676 cases(45.7%); Low birth weight were 49 cases(1.3%), normal birth weight were 3447 cases(94.1%), high birth weight were 169 cases(4.6%); 78 cases of premature infants (2.1%),3581 cases of term infants(97.7%),6 cases of postmature infants(0.2%); 79 cases of SGA(2.2%),2449 cases of AGA(66.8%),1137 cases of LGA(31%);In the way of delivery, cesarean section accounted for a major proportion, a total of 1929 cases(52.6%), and 1671 cases of vaginal delivery(45.6%).2. Among all 3665 cases of umbilical cord blood samples, mean for all umbilical cord blood glucose and lipid metabolism index is significantly lower than average level for general population, and the number accounted for a high proportion of overall.3.T test showed that the differences of distribution with statistical significance between male and female in newborns were ApoAl,ApoB,HDL-C,LDL-C,TC and Ins(P<0.05);all glucose and lipid metabolism index were statistically significant between different ways of delivery in newborns(P<0.05); the differences of distribution with statistical significance between different umbilical and amniotic fluid statues in newborns were HDL-C, TC,C-P (P< 0.05). Variance analysis showed that LDL-C and TC concentrations have significant difference among three different gestational age groups(P< 0.05); ApoA1,HDL-C,C-P and Ins concentrations have significant difference among three different birth weight groups(P<0.05); ApoA1,HDL-C,TC,TG,C-P and Ins concentrations have significant difference among three different weight and gestational age groups(P<0.05).4.Multiple linear regression showed that way of delivery has a greater impact on ApoA1,ApoB,Lp a,TG,HbA1c and Ins;gender has a greater impact on HDL-C,LDL-C and TC;WGA has a greater impact on C-P.Conclusions:(1) Birth conditions like gender, WGA are the important factors that affect neonatal glucolipid metabolic indices; (2) Girls’ LDL-C and TC level is significantly higher than boys; (3) Neonatal umbilical cord blood LDL-C.TG level is negatively correlated with birth weight, LDL-C for low birth weight newborns is in a high level; in SGA group,TG level increased significantly;(4) Umbilical cord blood C-P and insulin increased accordingly with birth weight, and are positively correlated with WGA.And suggesting that high C-P and insulin level may be a risk factor for LGA.