Study On Pharmacological Effect And Application By Cuiju(Chrysanthemum)

Cuiju is a cultivation and development kind of chrysanthemum. To validate there is a pharmacological action and prospect of application in Cuiju, experimentize with content inspection, antibiosis experiment. Confirm antipyretic effect, invigorate the circulation of blood effects, antilipemic effect and anti-oxidation effect of Cuiju according to the constructed animal model. It is illustrated that the effect of Cuiju was better than or as well as Chrysanthemum morifolium in these respect. Logical proofs is provided for the medicinal value and application prospect.The main results are as follows:1. extract Cuiju-polysaccharose in total sugar content. After that, measure Cuiju-polysaccharide content. Chrysanthemum morifolium and Dendranthema indicum. It turned out that the highest extraction yield of Cuiju-polysaccharide was 29% material to liquid is 1:25 by water extract and ethanol precipitation. Measure impurity elements contents and total sugar content in Cuiju through colorimetric method, So, it is confirmed that there is the highest percentage of magnesium, zinc, manganese and total sugar content in Cuiju. What can explain the cause of excellent taste and thickly-mellow of Cuiju.2.it is confirmed that there is anti-bacterial effects in vitro of Cuiju through medicine sensitive experiment of the method of plating, antibacterial ability of Cuiju surpass Chrysanthemum morifolium, however, is worse than Dendranthema indicum. Measure minimal inhibitory concentration by tube method, verify broad-spectrum antibacterial property of Cuiju.3.Construct a fever model for wistar. The temperature of the wistar will drop to normal range after gavage in 1.5 hours. It is tested that the pungent-cool diaphoresis effect of Cuiju is same as Chrysanthemum morifolium. It can replace Chrysanthemum morifolium to treat wind-heat type common cold.4.Construct a stasis of blood mode for wistar. Discover Cuiju lower whole blood viscosity and plasma viscosity of the wistar obviously. There is an evident activating blood to remove stasis in Cuiju.5.Construct a lipid metabolism disorder model for mice, wistar and rabbit. Measure molecular biological marker what is closely link to lipoproteins metabolism. It turned out that Cuiju reduce cholesterol-reducing and triglycerides for mice. Adjust lipid metabolism disorder for wistar. Meanwhile, reduce the contents of cholesterol and lipid peroxide of the experiment wistar remarkablely. The effect of lowering cholesterol of Cuiju is less than luvastatin. This shows that the efeect of Antifebrile, sterilization and lowering cholesterol of Cuiju.6.it is researched that the antioxident activity in Cuiju via constructing an oral decoctionmodel for mice. It turned out that, compared with those of control group, the oral decoctionmodel mice can alleviate oxidative stress effect by Cy alexin induction, regulating up T-AOC level, heightening T-SOD, CAT and GSH-PX activation in immunosuppressionmice serum, Lowering the MDA and carbonyl carbon level in serum. It is illustrated that there is the antioxident activity in Cuiju.Analyse comprehensively the consequence of antibiosis, pyretolysis, activating blood to remove stasis, hypolipidemic effects and so on in pharmacology effect. Parmacological actionquite of Cuiju is quite similar with Chrysanthemum morifolium, and the effect of Cuiju was better than Chrysanthemum morifolium in some respect. It can be deduced that Cuiju will be an ideal substitute of Chrysanthemum morifolium. There is a wide exploitation and application prospects in Cuiju, such as clinical therapy, health care, or as herb feed additives which ensure the safety of consumers, and produce green animal feed.