The Clinical Value Of Copeptin In The Severity Assessment Of Chronic Obstructive Pulmonary Disease

Objective:To investigate the clinical value of copeptin in the severity assessment of acute exacerbation chronic obstructive pulmonary disease(AECOPD). Method: We selected 100 patients with AECOPD as case group. According to the GOLD grading, they were divided into 4 subgroups: GOLD1 grade group(n=19), GOLD2 grade group(n=26),GOLD3 grade group(n=31), GOLD4 grade group(n=24). 100 healthy people were selected into the control group. All the patients underwent standard COPD treatment for10 days. Plasma copeptin and pulmonary function levels of all subjects were measured before and after treatment. We analyzed the relevance between copeptin level and pulmonary function of COPD patients in different grades. Result:(1)In case group,plasma copeptin level of acute exacerbation phrase is much higher than stable phrase. The difference is statistically significant(P<0.05). The copepin level is higher in stable phrase than that of the control group. The difference is statistically significant(P<0.05).(2)The plasma copeptin levels gradually raised in control group, GOLD1 group, GOLD2 group,GOLD3 group and GOLD4 group. The differences of plasma copeptin levels and pulmonary function grades among each group are statistically significant(P<0.05).(3)There is a negative correlation between the copeptin level and lung greade in different stage of COPD(rcopeptin=-.0.867, P<0.05). Conclusion: Copeptin in the healthy population is significantly lower than the COPD patients. Copeptin level is gradually raised as COPD worsens. Copeptin is negatively correlated with pulmonary function. Copeptin can reveal the severity of COPD, especially in the acute exacerbation phrase. This will provide a detection method to the diagnosis of COPD and has certain value in clinical application.