Clinical Analysis Of 21 Cases Of Small Cell Carcinoma Of The Cervix

Objective:To probe into the clinical features of and the therapeutic options and prognostic factors for small cell carcinoma of cervix(SCCC). Methods:Retrospective analysis was performed on clinical data collected from 21 patients with SCCC admitted to Oncology Hospital of Xinjiang Medical University from July 1, 2007 to June 30, 2014, for exploration of their clinical features and prognostic factors. Results:Among the 21 patients with SCCC, the age at initial diagnosis was 30-60 years with the median 45 years. According to the FIGO staging criteria 2009, 16 of them were assessed as stages ⅠB-ⅡB, and 5 as stages ⅢB-Ⅳ. By June 30, 2015, the follow-up cutoff date, a total of 4 patients had been lost to follow-up, and 8 of the rest 17 had been noted with distant metastasis to liver, lung, brain and bone, including 2 with local relapse; the survival time for the 5 patients who had died was 4, 8, 11, 12 and 24 months, respectively, and only 8 patients had survived free of disease. Among the 17 patients, the disease-free survival was 3-87 months with the median 27.0 months, and the overall survival was 4-95 months with the median 27.0 months; the median survival in the patients initially diagnosed at ≥45 years and <45 years was 18.0 months(95%CI:9.2-26.8) and 44.0 months(95%CI:16.3-71.7), respectively, P=0.008; the median survival in the patients with the tumor diameter ≤4cm and >4cm was 44.0 months(95%CI: 17.7-70.3) and 18.0 months(95%CI: 6.9-29.1), respectively, P=0.014. Among the 13 patients with SCCC who underwent surgery, the median survival in the patients with pelvic lymph node metastasis and without metastasis was 8.0 months(95%CI: 0-21.7) and 35.0 months(95%CI: 17.5-52.5), respectively, P=0.005. Conclusions:For SCCC, a rare gynecologic malignant tumor, the preferred therapeutic option is surgery combined with chemotherapy at early stages, and radiotherapy combined with chemotherapy at advanced stages. It was inferred that age at initial diagnosis≥45 years, tumor diameter>4cm and pelvic lymph node metastasis presented the potential predictors for poor diagnosis.