| Purpose:Evaluating the clinical effect of using Shounian powder and Sini powder to treat the moderate cancer pain of Qi stagnation blood stasis syndrome.Discussing the therapies of the moderate cancer pain of Qi stagnation blood stasis syndrome.For the treatment of moderate cancer pain of Qi stagnation blood stasis syndrome of TCM therapy provides the referential therapies,means and approaches.Method:This subject is based on the principle of randomized controlled,and is divided into the treatment group and the control group.According to the inclusion criteria to choose 72 cases, 36 cases were randomly divided into treatment group and others were divided into control group.The control group:the primary disease foundation treatment and oral the Ibuprofen and Codeine Phosphate Tablets(2 piece/time, Bid).The treatment group: the primary disease foundation treatment,oral the Ibuprofen and Codeine Phosphate Tablets(2piece/time, Bid)and oral the Shounian powder and Sini powder(1 bag/time,250ml/bag,3 times/day,3 bags/dose). Both groups used 2 weeks for one period of treatment, were observed 1 course of treatment. The Symptoms of TCM,quality of life(QOL), KPS score and pain assessment of the cancer pain patients who were of qi stagnation and blood stasis type moderate were observed before and after treatment,then evaluating the clinical curative effect with this prsecription.Results:1.In terms of NRS scores: according to the statistical analysis, the comparison in NRS scores of treatment group and control group after medication is significant(P=0.05), the NRS score of treatment group and control group before andafter medication was also significant(P=0.000<0.01); So after medication the NRS scores of the two groups are reduced significantly, and that of treatment group after medication decreased significantly in the control group after medication.2.Pain in patients with curative effect: according to the statistical analysis,the comparison in pain curative effect of treatment group and control group after medication is significant(P=0.008<0.01), that the treatment group’s pain effect was obviously better than the control group’s.3.In aspect of to improve the curative effect and TCM symptom integral:according to the statistical analysis, the two groups before and after medication comparison of TCM syndrome symptoms integral is significance(P=0.000<0.01),the integral comparison among the two groups of TCM syndrome symptoms also has significance(P=0.01<0.05), and the comparison of TCM symptoms curative effect after medication of the two groups is also significant(P=0.009<0.01);That the TCM syndrome symptoms integral of the two groups were significantly improved before and after drugs, and the treatment group on the improvement of TCM syndrome symptoms integral more than in control group after medication, treatment group on the improvement of TCM symptoms curative effect is also more than in the control group.4.In terms of KPS score and QOL scores: according to the statistical analysis,before and after medication the two groups of KPS score, QOL score are all significant(P = 0.000 < 0.01, P = 0.000 < 0.01), but the comparison between treatment group and control group after medication in KPS score, QOL score are meaningless(P=0.102>0.05, P=0.28>0.05); Before and after medication the two groups of KPS score, QOL scores were significantly improved, but no obvious difference was found in KPS score and QOL score between two groups after medication.5.The data of blood rheology in patients: according to the statistical analysis,in the two groups after medication the blood rheological data comparison had no statistical significance(P > 0.05). After medication the average of two groups in ESR,plasma viscosity and blood viscosity still were greater than normal;The HCTaverage is still less than normal. Before and after medication the comparison is maked in the two groups, in treatment group the plasma viscosity after medication were significantly reduced than before medication(P=0.000<0.01), HCT and blood viscosity 200 after was significantly greater than before medication(P=0.004<0.01,Pgirl=0.003、Pboy=0.008<0.01), ESR and blood viscosity was no significant difference before and after medication(Pgirl=0.099、Pboy=0.065>0.05,Pgirl=0.18、Pboy=0.722>0.05);There was no significant difference of the control group before and after medication in the data of blood rheology(P>0.05). That after medication two groups of blood rheology data is no difference between groups.Comparison before and after drug treatment group itself, in addition to the ESR and blood viscosity 1 no change,plasma viscosity, HCT and blood viscosity 200 were improved; The control data of blood rheology in no obvious change before and after medication.6.Safety index data: the routine blood(RBC, WBC, PLT), hepatic function(ALT, AST), renal function,(Cr, UREA), and blood coagulation function(PT, APTT,FIB), such as statistical analysis, the comparison of the two groups before and after medication in the way, or after drugs comparison between the two way had no statistical significance(P>0.05).Conclusion:Shounian powder and Sini powder can obviously reduce NRS score of Patients with moderate pain with Qi stagnation blood stasis syndrome, and can effectively improve the symptoms of TCM, this method in the aspect of control moderate pain with Qi stagnation blood stasis syndrome is safe and effective, and no obvious adverse reaction. |
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