Clinical Efficacy And Safety Of Adhesion Prevention Measures In Preventing Postoperative Abdominopelvic Adhesions: A Meta-analysis

Objective: To assess the clinical effectiveness and safety of biological adsorbable anti adhesion membrane( Hyaluronic Acid HA-CMC) in preventing postoperative abdominopelvic adhesions.Methods: The following databases such as PubMed、OVID、Spring、CNKI、CBM、Wanfang data were searched to collect the randomized control trails(RCTs) about the clinical effectiveness and safety of biological adsorbable anti adhesion membranein preventing postoperative abdominopelvic adhesions. According to the inclusion and exclusion criteria to search studies, extracted data, and evaluated the methodological quality. The meta-analysis was performed using Rev Man software version 5.3.Results: Seven randomized controlled trials were included. In the aspect of validity,meta-analyses showed that compared with the control gruop, The incidence of adhesions have statistical significance. The incidence of adhesions degree level2, level3 have statistical significance; The incidence of adhesions degree level 1 have no statistical significance; The incidence of adhesions scope level 2, level3 have statistical significance;The incidence of adhesions scope level 1 have no statistical significance;In the aspect of safety, meta-analyses showed that compared with the control gruop,The intraoperatve blood loss have statistical significance; Postoperative intestinal obstruction,abdominal abscess,the incidence of wound infection,high fever were not statistically significant.Conclusion: Application of adsorbable anti adhesion membrane in the operation can reduce the incidence of abdominopelvic adhesion,reduce the degree of adhesion, reduce the scope of adhesion, reduce the intraoperatve blood loss;But the abdominal abscess,intestinal obstruction,wound infection and the incidence of postoperative adverse reaction such as high fever is similar.