A Review Of Childhood Tuberculosis In The Area Of Xinjiang

Objectives: Researching on children with tuberculosis of demographic, clinical manifestations, radiographic, diagnosis and treatment about The First Affiliated Hospital of Xinjiang Medical University and The Children’s Hospital of Urumqi City and Urumqi Chest Hospital, to Help improve the understanding of the clinical pediatrician about the level of diagnosis and treatment of tuberculosis in children. Methods: We conducted a retrospective case series study of children Age less than or equal to 15 years old with bacteriologically confirmed or clinically diagnosed TB of the Hospital Mentioned Above from the January 2013 to June 2015. Results: 236 children were identified: 56% male,53% Uygur, 54% in southern Xinjiang, 96% with BCG vaccination, 11% with known TB contact, and 86.5% with basic diseases. Intrathoracic TB was present in 62%,extrathoracic in 53%. The most common extrathoracic manifestation was peripheral lymphadenitis, and children under 3 were more likely to have miliary TB or both intra and extrathoracic TB. Fever and failure to thrive were common presenting symptoms among all participants(65% and 60%, respectively), 66% of those with intrathoracic TB presented with cough, and those with TB meningitis presented with severe neurologic impairment, mycobacterial cultures were positive in 4% and 3% of children tested, and The positive rate of PPD was 92%, The positive rate of TSPOT was 98%. Among the 62%children during hospitalization treatment for 2RHZ+4RH, 14% children with treatment plan for 2RHZS+4RH. Conclusions: Tuberculosis, more men than women in rural areas than the city, Uighur more than other ethnic; southern more than northern; more than children with underlying diseases; thoracic tuberculosis type is common in children with tuberculosis; high PPD test, TSPOT detection positive rate of pulmonary tuberculosis; CT can show the chest can not be found in lymph nodes, calcification and cavity.