The Clinical Study Of High Sensitivity C-reactive Protein And Neutrophil-to-lymphocyte Ratio With Chronic Heart Failure

Objective: To investigate the association of high sensitivity c-reactive protein(hs-CRP), neutrophil-to-lymphocyte ratio(NLR) level with the cardiac structure and function in patients with chronic heart failure. Methods: Three hundred and two patients with chronic heart failure in our hospital between February 2014 and October 2015 were analyzed. According to the different levels of hs-CRP, the patients were divided into four groups: group I(<2.5mg/L), group II(2.5-5mg/L), group III(5.1-11mg/L) and group IV(>11mg/L). According to the different levels of NLR, the patients were divided into two groups: group A(<2.25) and group B(≥2.25). Each patient received examinations of blood routine, blood biochemistry, hs-CRP, electrocardiogram and echocardiography. The differences of the general data, echocardiography parameters and NYHA classification of patients were compared and analyzed in each group. The association of hs-CRP and NLR with cardiac structure and function were investigated with appropriate statistical methods. Date analysis was performed by using the Statistical Package for Social Sciences(SPSS17.0). The value of P<0.05 was considered significant for all tests. Results:(1) According to the different hs-CRP, there was significant difference in NYHA classification, LVEF, LVFS, LAD, LVESD, LVEDD and LVMI among the four groups(P<0.01). There were significant positive correlations between the hs-CRP and NYHA classification, LAD, LVESD, LVEDD, LVMI. Furthermore, there were negative correlations between the hs-CRP and LVEF, LVFS.(2) According to the different NLR, there was significant difference in NYHA classification, LVEF, LVFS, LAD, LVESD, LVEDD and LVMI between the two groups(P<0.01). There were significant positive correlations between the NLR and NYHA classification, LAD, LVESD, LVEDD, LVMI. Furthermore, there were negative correlations between the NLR and LVEF, LVFS. Conclusion: The level of hs-CRP and NLR maybe can reflect the change of cardiac structure and function in patients with chronic heart failure. With an increase in hs-CRP and NLR level, LAD, LVESD, LVEDD, LVMI increased, NYHA classification increased either, however, LVEF and LVFS decreased, cardiac function become worse.