The Relationship Between Microinflammation And Vascular Calcification In Patients With Chronic Kidney Disease

Objective: To investigate the relationship between neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),serum high-sensitivity C-reactive protein(hsCRP)levels,microinflammation and vascular calcification in patients with chronic kidney disease.Methods: This study included 148 patients with chronic kidney disease from January 2017 to December 2018 in our hospital.The results of whole blood cell analysis,serum hsCRP,other test indexes,cardiac ultrasound and carotid artery ultrasound were collected.To analyze the relationship between NLR,hsCRP and cardiac valve calcification,carotid plaque in patients with chronic kidney disease,and the risk factors of cardiac valve calcification in patients with chronic kidney disease.Results: The levels of NLR,PLR and hsCRP in patients with hemodialysis were significantly higher than those in patients without hemodialysis.The levels of NLR,PLR and hsCRP in patients with chronic kidney disease with cardiac valve calcification were significantly higher than those in patients without cardiac valve calcification.Multivariate logistic regression showed that elevated NLR and hsCRP were independent risk factors of the occurrence of cardiac valve calcification in patients with chronic kidney disease.(P < 0.05).Conclusion: In patients with chronic kidney disease,microinflammation is more obvious in hemodialysis patients than in non-hemodialysis patients,and the incidence of cardiac valve calcification is higher.NLR,and hsCRP are important for assessing microinflammation and risk of cardiac valve calcification in patients with chronic kidney disease.The elevated levels of NLR and hsCRP are independent risk factors for cardiac valve calcification in patients with chronic kidney disease.