| To investigate the causes and digital subtraction angiography(DSA)features of ischemic stroke in youth, we retrospectively analysed 65 inpatients who suffered from cerebral stroke in the past five years(2010.09-2015.11) hospitalized in the 2nd Neurology Department,China-Japan Friendship Hospital Affiliated to Jilin University. Meanwhile,data on 164 inpatients with older age stroke onset(>65 years old) at the same period were collected as aged group. The age at stroke onset of the youth group was between 18-45 years old(Male:Female=40:25). DSA was performed in both groups.Results:In youth stroke, 30 cases were due to atherosclerosis(46.15%), 10 patients caused by moyamoya disease(15.38%), 7 cases by cerebral arteritis(10.77%), 6 cases by cerebral artery dissection, 1 case by fibromusclar dysplasia(1.54%), and 13 cases were due to unknown causes(20.00%).The risk factors for ischemic stroke in youth cohort were smoking and / or binge drinking(46.15%), hypertension(38.46%),hyperlipidemia(27.69%), diabetes(15.38%), and family history(12.31%).Among the 30 youth stroke cases caused by atherosclerosis, DSA showed vascular lesions in 45 locations, among which there were 5vascular occlusions, 10 severe stenosis, 15 moderate stenosis, and 15 mild stenosis. 20 cases only had one lesion and 10 cases had two or above lesions. There were 36 intracranial vascular lesions and 9 extracranial vascular lesions in total in the youth cohort. There were 30 collateral circulation(Willis) vessels opening(20 unilateral and 10 bilateral).Among 108 patients with atherosclerotic ischemic cerebral stroke,DSA showed vascular lesions in 226 locations, among which there were55 vascular occlusions, 62 severe stenosis, 73 moderate stenosis, and 36 mild stenosis. 33 cases only had one lesion, and 75 cases had two and above lesions. There were 63 intracranial vascular lesions, and 163 extracranial vascular lesions in total in the aged stroke cohort. There were168 collateral circulation(Willis) vessels opening(96 unilateral and 72bilateral).Compared with aged stroke group, one atherosclerosis lesion and intracranial vascular disease are more common in the youth group, while extracranial vasculopathy is commonly seen in the aged stroke group with more than two vascular lesions. There was no significant difference between the two groups in terms of collateral.Conclusion:This study highlighted the different causes and DSA features of ischemic stroke between youth and aged onset groups, indicating different prevention and therapeutic approaches shall be applied toischemic stroke in youth. |
