Changes Of Serum Creatinine, Cardiac Troponin And High Sensitive C Reactive Protein In Different AECOPD Severity

Objective : Analyzed the changes of serum creatinine, cardiac troponin and high sensitive C reactive protein in different AECOPD severity.Object: Inclusion of patients from May 2014 to May 2015 admitted in the respiratory department diagnose were acute exacerbations of chronic obstructive pulmonary disease, a total of 365 people, including male 173 and 192 women, average age(63.11±12.52) years old. Inclusion criteria accorded with the criterions of the 2011 the diagnosis and treatment of chronic obstructive pulmonary disease(COPD), admission in acute stage. Exclusion criteria: acute phase disease in the past 4 weeks, oral corticosteroids, and other diseases with elevated levels of inflammatory protein.Methods : After being admitted to the hospital,pulmonary function tests in patients with blood sampling detection of high sensitivity C-reactive protein, serum creatinine and troponin was performed. Integrated patient clinical manifestation and the pulmonary function severity of patients for clinical group: mild, moderate and severe patients respectively 81, 173 and 111. Through the SPSS software to deal with the above data, finally the relevant conclusions were drawn.Results : Different groups of patients with high sensitivity C reactive protein, creatinine, and troponin values were as follows: light, medium and severe patients were 7.54(3.25-11.78), 7.73(4.71-24.60) and 14.70(6.94-47.00), respectively;the creatinine values of the three groups were 59.98 ± 66.22, 8.62 ± 11.83, 68.25 ± 9.97, respectively; light, medium and severe groups, the troponin values were 0.01(0.01-0.01), 0.02(0.01-0.02), 0.04(0.015-0.05).(1) Different levels of pulmonary function in patients with FEV1 accounted for the estimated value of% of the value of the difference, with the increase in the severity of the disease, FEV1% predicted was expected to be reduced, the difference was statistically significant(P <0.05).(2) In mild, moderate and severe groups AECOPD patients with high sensitivity C reactive protein comparison, with the expected decline in the expected value of FEV1% predicted, high sensitivity C reactive protein, a positive correlation, the difference was statistically significant(P <0.05).(3) In mild, moderate, severe groups AECOPD patients with creatinine comparison, with the FEV1% predicted was expected to decline, creatinine, value increased, there was a negative correlation between the groups, the difference was statistically significant(P < 0.05).(4) There was a negative correlation between FEV1% predicted and cardiac troponin in patients with mild, medium and severe groups AECOPD, and the difference was statistically significant(P < 0.05).Conclusion: 1. Serum CRP can be used as a biological indicator to reflect the severity of AECOPD. With the decrease of lung function, CRP gradually increased. 2. The negative correlation between FEV1 percentage of predicted value% and creatinine are positively correlated with AECOPD in patients with chronic obstructive pulmonary disease. 3. The correlation between FEV1 percentage of predicted value% and troponin in AECOPD patients was negative in the present study, which reflects the damage of chronic obstructive pulmonary disease.