A Retrospective Analysis:Bacterial Infection Is Associated With Persistent Wheezing Of Young Children And Antibiotic Treatment Is Effetive

Objective To investigate the relevance of bacteria colonization in the lower respiratory tract (LRT) and persistent wheezing of infants and young children, in order to comprehensively analyze such children and find guidance of antibiotic usage between them in clinically. Methods We got 136 BALF specimens from infants and young children with persistent wheezing, and analyzed the pathogen in BALF culture, the viral antigen(RSV, Adv, IVA、B, PIV1、2、3) of nasopharyngeal aspirate and MP-PCR, CP-PCR. Further, we divided the cases with positive bacterial isolates into two groups based on if they were administered with antibiotics. The symptom scores of wheezing, coughing, wheezing sound and rale in the 3rd day, and the 5th day were recorded. Results 1. There are 30(22.0%) cases with virus positive,10(7.4%) with MP-PCR positive,0(0%) with CP-PCR positive,67 (49.3%) with positive bacterial isolates, including 22 (27.8%) cases of pneumococcal pneumonia,9 (11.4%) cases of Klebsiella pneumoniae pneumoniae subspecies,7 (8.9%) cases Haemophilus parainfluenzae.2. The antibiotic group and the control group could both improve the children’s symptom scores of wheezing, coughing, wheezing sound and rale, and the differences of the symptom scores before and after treatment between the 2 groups were statistically significant (6.293±1.792、 5.500±2.083 vs 2.537±1.399.3.885±1.275)(S=820、181, all P<0.05).3. The antibiotic group had more improvement at the symptom scores of wheezing, coughing, wheezing sound and rale than those of the control group in the 3rd day(0.585±0.706、0.683±0.471、0.610±0.542、0.659±0.575 vs 1.000±0.566、0.962±0.445、0.962±0.528、0.962±0.528) and the 5th day(0.317±0.471、0.488±0.506、0.243±0.435、0.390±0.494 vs 0.692±0.618、0.808±0.402、0.615±0.697、0.692±0.549), and the differences of the symptom score were statistically significant(Z=2.811、2.26、2.482、 2.136、2.552、2.599、2.346.2.191, all P<0.05). Conclusions Bacterial colonization in the LRT maybe relevant in a portion of infants and young children with persistent wheezing, and antibiotic treatment may improve such children with wheezing, coughing, wheezing sound and rale significantly. Infants and young children with persistent wheezing can be improved after antibiotic treatment.