The Key Mediators In The Radiation Enteritis

Intestinal mucositis has become an better characterized toxicity of radiotherapy. Considerable evidence has indicated that the incidence of radiation enteritis is expected to continue to rise during the coming years paralleling the unprecedented use of radiotherapy in pelvic cancers. Radiation enteritis is better recognized as the loss of absorptive capacity of the intestine following irradiation. The pathology of radiation enteritis was characterized as the edema, the exudation, the necrosis and even the intestinal sclerosis, obstruction in the delay period. Recently, pathogenetic mechanism of the radiation enteritis has increasingly recognized aims to reduce the morbidity and provide better management. In this review we will discuss classes of agents as ROS, TLRs, MMPs, Thrombomodulin, and XRCC1 Protein other than the direct free radical scavenging thiols that modify radiation responses and will comment on how they might fit a conceptual framework of DNA, cell, and tissue responses to radiation damage.