The Effect Of Fluoxetine Combined With Shuganjieyu Capsule On Efficacy And Cognitive Function Of Depression

BackgroundDepression is a clinical syndrome characterized by persistent and significant depressing emotion. The disease has a serious impact on the work, study and life of the patients, which brings heavy burden to family and society. How to treat it more effectively and restore the social function of patients has become a very urgent problem. Chinese traditional medicine and Western medicine in the treatment of depression have characteristics, the target of Western medicine is clear, the effect is fast, curative effect is positive, but compliance is poor. Chinese traditional medicine more target, less side effect and good compliance, but the effect is slow. At present, the clinical application of Integrated Chinese and Western medicine treatment of depression has become a hot research.ObjectiveComparison of fluoxetine combined with ShuganJieyu capsule and fluoxetine monotherapy on depression in patients with recent clinical efficacy and differences, compared fluoxetine combined with ShuganJieyu capsule and fluoxetine monotherapy on cognitive function in patients with depression and differences, for the clinical treatment of depression provides theoretical basis.Methods1.This study adopts randomized controlled method, patients aged 18-55 years; with the diagnostic criteria of depression; HAMD scores≥18 for inclusion criteria, select 120 cases of patients as the research object, divided into the observation group (60 cases) and control group (60 cases). Observation group was given fluoxetine 20mg/d, the morning taken at a draught, combined with ShuganJieyu capsule 2 pills/times, take one time in the morning and evening, while the control group was given fluoxetine 20mg/d, the morning taken at a draught. The clinical observation of all the patients for 8 weeks,113 cases were completed and data statistics, including 57 cases in the observation group,56 cases in the control group.2. Hamilton Depression Scale (HAMD) and Treatment Emergent Symptoms scale (TESS) were used to study. The reduction ratio of HAMD score was observed, and the adverse drug reactions of TESS were observed. Wisconsin Card Sorting Test (WCST) and event related potential P300 assessment effect on cognitive function.3. Data were statistically analyzed using SPSS18.0 software. T test, F test or Chi-square test were used to test the data. The statistical results were statistically significant with P<0.05.Result1. The total effective rate of the observation group and the control group were 82.5% and 73.2%, according to the HAMD score of the two groups before treatment and 8 weeks after treatment. There was no significant difference in total effective rate between the two groups (P>0.05). The HAMD score of two groups after 2 weeks,4 weeks,8 weeks treatment, compared with before treatment were significantly different (P<0.05). The reduction ratio of HAMD score between the two groups was compared, the difference between the two groups was significant (P<0.05) after 2 weeks, and the difference between the two groups was not significant (P>0.05) after 4 and 8 weeks. It was found that there were significant differences (P<0.05) between the two groups of patients before and after treatment with anxiety/somatic factors, retardation factor and Sleep disorder factor. There was no statistical significance (P>0.05) of the difference between body weight factors. After treatment, the scores of anxiety/somatic factor, retardation factor and sleep disorder factor in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05).2. WSCT:After treatment 8 weeks the two groups of the total responses, the random error number, and persistent error number were significantly lower than before treatment (P<0.05). After treatment, the total response, persistent error number of observation group less than that of the control group, the difference is statistically significant (P<0.05). P300: The latency of P300 in the two groups were shorter than those before treatment (P<0.05), and the amplitude of P300 in the two groups were significantly higher than those before treatment (P<0.05), but the latency of P300 in the observation group was significantly shorter than that in the control group (P<0.05).3. The incidence of adverse drug reactions in the observation group and the control group was 21.1%(12/57),23.2%(13/56), and there was no significant difference between the two groups (P>0.05).Conclusion1. Fluoxetine combined with Shuganjieyu capsule in the treatment of depression always has the same efficiency with fluoxetine monotherapy, but early curative effect is better than that of fluoxetine monotherapy. For HAMD score anxiety/somatic factor, retardation factor and sleep disturbance factor scores were higher in patients can be by fluoxetine combined with Shuganjieyu capsule treatment options.2. Fluoxetine combined with Shuganjieyu capsule on cognitive function in depression better than fluoxetine monotherapy.3. Fluoxetine combined with Shuganjieyu capsule did not lead to increased adverse drug reactions.