Clinical Study Of Dingtongzhixietang Combinnation With Efficacy Of Probiotics In The Treatment Of Diarrhea-apredominant Irritable Bowel Syndrome (Liver Depression And Spleen Deficiency Syndrome)

Objective:Toobservetheclinical efficacyand safety of the Dingtongzhixietang combinnation with Efficacy of probiotics in the treatment of diarrhea-predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome).Methods:Ninety cases of diarrhea-predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome) patients were randomly divided into two group, treatment group(n=45, treated withDingtongzhixietang&Compound Eosinophil-Lactobacillus Tablets), control group(n=45, treated with Compound Eosinophil-Lactobacillus Tablets), course of treatment is four weeks. Then the two group’s indicators of total symptom score and the clinical symptom score, adverse reactions were observed and compared before and after treatment, using SPSS 19.0 statistical software to evaluate the clinical efficacy and follow up the recurrence after one month.Result:1、The efficacy analysis:The treatment group, nine cases were cured, sixteen cases were markedly effective,ten cases were effective, five cases were invalid, five cases were lost, the total effective rate was 87.5%; the control group, two cases were cured,tencases were markedly effective, fourteen cases were effective, sixteen cases wereinvalid, three cases were lost, the total effective rate61.9%,the treatment group’s total effective rate is higher than that the control group’s. After statistical analysis, the total effective rate of the treatment group compared with the control group was difference (P> 0.05).2、Efficacy analysis of clinical symptoms:The total score of the clinical symptoms of the two groups of patients were significantly improved after treatment (P<0.05). But the treatment group was better thanthe control group in improvingthe total score of the clinical symptoms(P＜0.05). Some symptoms of the treatment group could be more significantly improved than the control group (P <0.05), such as the degree of abdominal pain or discomfort, number of episodes of abdominal pain or discomfort,defecation frequency,fullness in chest, hypochondria and lower abdomen, Diarrhea aggravate when emotional stress or depression, eructation, preference for sighing, fatigue. There was no significant difference between the two groups in improving stool texture.3、The recurrence rate:The treatment group, nine cases were recurrence,the total recurrence rate was 17.5%; the control group, nineteen cases were recurrence,the total recurrence rate was 45.2%.The total recurrence ratebetween the treatment group with the control group was difference and the treatment group could be more significantly improved than the control group (P<0.05).4、Security:The two groups of patients did not appear the phenomenon of allergies and intolerancesduring the treatment, and there were no significanttoxic side effects.Conclusion:Dingtongzhixietang combinnation with Efficacy ofprobiotics in the treatment of diarrheapredominant irritable bowel syndrome (liver depression and spleen deficiency syndrome)is safe and effective.lt is good in remitting the clinicalsymptoms, reducing the recurrence rate.