The Relationship Between Serum Homocysteine Levels With Type 2 Diabetes Association

Objective:Diabetes is a global major public health problem in the world within the scope of diabetes is the third largest after cardiovascular and tumor disease threat to human health. At the same time, the great vessels, microvascular complications of diabetes with peripheral neuropathy and is a major chronic complications of diabetes, serious harm to people’s life safety. In recent years, high homocysteine levels, begins to be the concern of the people. This study used the same period in patients with type 2 diabetes and the control group of case-control study, patients with type 2 diabetes mellitus serum homocysteine(Hcy) levels and the relationship between the traditional risk factors and diabetes.Subjects and Methods:In October 2013 to December 2014 the first people’s hospital of kunshan city at the records of 95 patients with type 2 diabetes endocrinology as the research object, and at the same time with the court ruled out of the cardiovascular system, digestive system and malnutrition of spine surgery, joint surgery, 2013, and physical examination of 395 cases of hospitalized patients as control group, all entrants in nearly three months is not taking folic acid, vitamin B6, vitamin B12, collect the patient’s demographic information, life style, clinical features, laboratory examination, history etc. Using roche MODULAR_DP automatic biochemical analyzer test patients admitted to hospital 24 hours of homocysteine concentrations.Using multiariable logistic regression model analysis of homocysteine levels and the relationship between the traditional risk factors and type 2 diabetes, calculate the OR and 95% CI, and carry on linear trend test. According to age, sex, heart rate, BMI, blood lipid and smoking is divided into several subgroups, analysis of homocysteine levels in every subgroup and the correlation of diabetesResults:Overweight people with diabetes risk was 6.67 times that of the normal(95% CI: 3.81, 11.68); With HDL- C level 1.14 OR higher tendency than L, levels of HDL- C < 1.14 tendency of diabetes OR L(95% CI) was 2.68 times(95% CI: 1.50, 4.78); LDL- C < 2.18 tendency for LDL- C L is the risk of diabetes OR greater tendency for 2.18 L of 2.27 times(95% CI: 1.09, 1.09) in smokers, the risk of diabetes was 5.05 times that of the non-smokers(95% CI: 1.72, 14.81), drinkers of diabetes risk was 0.28 times of nondrinkers(95% CI: 0.09, 0.89), with Hcy < 15 mu mol/L compared with patients, Hcy 15 mu OR mol/L outcome in patients with diabetes OR(95% CI) is 0.84(0.41, 0.41). BMI, HDL, LDL- C- C and dose-response relationship between drinking smoking and diabetes(P < 0.05), and Hcy levels and no significant dose-response relationship between diabetes(P > 0.05).Conclusion:1. The BMI, HDL- C, LDL- C and smoking significantly increased the risk of diabetes. 2. Drinking may reduce the risk of diabetes. 3. This study did not find the relationship between Hcy levels and diabetes.