Relationship Between TCM Syndrome Type And Homocysteine In Perivascular Disease Of Type 2 Diabetes

Objective:By studying the distribution of TCM syndrome type in patients with type 2diabetic peripheral vascular disease and the correlation between TCM syndrome type and clinical index,it provides objective dialectical basis for TCM syndrome differentiation and prevention.Methods:From December 2019 to December 2020,the case data of T2 DPVD patients received by the outpatient and inpatient department of Endocrinology Department in Xi’an traditional Chinese Medicine Hospital,Based on inclusion and exclusion criteria,A total of185 patients were collected as subjects,Referring to the standard of clinical diagnosis and treatment established by Endocrinology Department of Xi’an traditional Chinese Medicine Hospital,Combined with syndrome,tongue,pulse,It is divided into four groups: Yin deficiency internal heat and blood stasis,liver stagnation and spleen deficiency and blood stasis,phlegm dampness and blood stasis,Yin and Yang deficiency and blood stasis.General data and clinical indicators of 185 T2 DPVD patients recorded,including sex,age,height,weight,BMI,duration of diabetes,fasting blood glucose(FPG),postprandial2-hour glucose(2h PG),glycosylated hemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC),low lipoprotein(LDL-C),high density lipoprotein(HDL-C),serum homocysteine(Hcy),ankle brachial index(ABI)and other indicators,Collate the collected data into the excel form,SPSS22.0 software is used for data analysis and processing.Result : 1.In the distribution of syndrome type,the number and proportion of yin deficiency,dryness and heat and blood stasis syndrome were the largest,and the number and proportion of yin and yang deficiency and blood stasis syndrome were the smallest.2.In terms of gender,although the overall proportion of men is greater than that of women,there is no significant difference between the syndromes and gender distribution(P>0.05).3.In terms of age,T2 DPVD the four groups of syndromes,Yin and Yang deficiency and blood stasis syndrome were the oldest,liver stagnation and spleen deficiency and blood stasis syndrome were the youngest.The difference was not statistically significant(P<0.05).4.In the course of disease,T2 DPVD the four groups of syndromes,liver stagnation and spleen deficiency and blood stasis syndrome course is the shortest,Yin and Yang deficiency and blood stasis syndrome course is the longest,the difference between the two groups is statistically significant(P<0.05).5.In BMI,There was no significant difference T2 DPVD the BMI of each group(P>0.05).6.In blood sugar,T2 DPVD the four groups,Yin deficiency and heat and blood stasis syndrome FPG the highest level,There was significant difference in FPG level between the two groups(P<0.01),and the FPG level of phlegm dampness and blood stasis syndrome is the lowest,compared with liver stagnation and spleen deficiency and blood stasis syndrome,yin and yang deficiency and blood stasis syndrome,the difference is significant(P<0.05).There was no significant difference in blood glucose between DPVD syndromes and 2 hours postprandial(P>0.05).Yin deficiency and heat and blood stasis syndrome HbA1 c the highest level,Compared with phlegm dampness and blood stasis syndrome(P<0.01),Compared with the other two groups,there was no significant difference(P>0.05).7.In terms of blood lipids,The TC,TG,HDL-C,LDL-C difference between the T2 DPVD four groups was statistically significant(P<0.05).TG in Yin deficiency,heat and blood stasis syndrome,And compared with the other groups,there were statistical differences(P<0.05),The mean value in phlegm dampness and blood stasis syndrome is the largest,Compared with Yin deficiency dryness and heat and blood stasis syndrome,liver stagnation and spleen deficiency and blood stasis syndrome,there was statistical difference(P<0.05).TC had the largest mean value in phlegm dampness,Compared with other groups,there was significant difference(P<0.05).HDL-C the mean value of Yin and Yang deficiency and blood stasis syndrome was higher than that of other groups,Compared with Yin deficiency and heat and blood stasis syndrome,phlegm dampness and blood stasis syndrome,there were significant differences(P<0.05).The mean value of LDL-C syndrome in yin deficiency and heat and blood stasis was higher than that in other groups(P<0.05),and the mean value of liver stagnation and spleen deficiency and blood stasis syndrome was the smallest.There was significant difference between liver stagnation and spleen deficiency and blood stasis syndrome(P<0.01).8.In terms of serum homocysteine,the mean value of Hcy was the highest in phlegm and dampness and blood stasis syndrome,which was statistically significant compared with Yin deficiency and heat and blood stasis syndrome,liver stagnation and spleen deficiency and blood stasis syndrome(P<0.05),and liver depression and spleen deficiency and blood stasis syndrome was the smallest(P<0.05).9.In terms of ABI,among the four groups,the ABI mean value of the patients with yin and yang deficiency and blood stasis syndrome was the smallest,which was statistically significant compared with the other groups(P<0.05).Conclusion:1.The distribution of common T2 DPVD syndromes in T2 DPVD patients decreased from yin deficiency dry heat with blood stasis syndrome,liver depression and spleen deficiency with blood stasis syndrome,phlegm dampness internal hyperplasia with blood stasis syndrome,yin and yang deficiency with blood stasis syndrome in turn.2.The distribution of T2 DPVD TCM syndrome types has nothing to do with gender and BMI,but is related to the course of the disease and age.Among them,patients with liver depression and spleen deficiency and blood stasis syndrome are the youngest and have the shortest course of disease,while those with yin and yang deficiency with blood stasis syndrome are the oldest and have the longest course of disease.3.In this study,FPG,HbA1 c,TG,TC,LDL-C,HDL-C,Hcy,and ABI are all closely related to the common T2 DPVD syndromes of T2 DPVD.Therefore,clinically,we must pay special attention to the above indicators for the T2 DPVD T2DPVD syndrome differentiation.influences.