Clinical Effects Of The Trea Tment Of Early Diabetic Nephropathy With Osteoporosis By Artificial Tiger Bone Powde R

Objective:By using the method of artificial tiger bone powder therapy,from the point of the changes of bone mineral density(BMD), 24 hours urinary calcium(24 h urine Ca), 24 hours urinary phosphorus(24 h urine P) and parathyroid hormone(PTH), alkaline phosphatase(ALP), urine micro albumin to creatinine ratio(urinary m Alb/Cr) and systemic symptoms of osteoporosis, to observe clinical effect of the artificial tiger bone powder therapy on typ2 diabetic with early diabetic nephropathy and osteoporosis. Under the guidance of Traditional Chinese Medicine(TCM) theory, a new way for the treatment of early diabetic nephropathy with osteoporosis is researched by using the method of integrated traditional Chinese medicine and western medicine.Methods: 102 cases of typ2 diabetic patients with early diabetic nephropathy and osteoporosis diagnosed and treated in our hospital during 2013-2014 were randomly divided into 3 groups. 34 patients in the Traditional Chinese medicine treatment group were treated with artifical tiger bone powder(JINTIANGE capsule), 3 pills each time, 3times a day; 34 patients in the Western medicine treatment group took Calcium D by600mg:125iu/day, calcitriol capsule 0.25 ug/day and Alendronate Sodium Enteric-coated Tablets 70 mg per week; The Combination of Chinese and western medicine treatment group were treated with artifical tiger bone powder(JINTIANGE capsule) on the basis of Western medicine treatment group with the previous dose usage, treatment for 24 weeks.Results:Through the clinical observation, the curative effect of traditional Chinese medicine treatment group and combination treatment group was better than western medicine treatment group(P<0.05); After treatment, there was a statisticant change of BMD values in each group(P<0.05). Compared respectively with traditional Chinese medicine treatment group and western medicine treatment group, the change was more significant in combination treatment group(P < 0.05); After treatment, urine m Alb/Cr in each group decreased distinctly(P < 0.05); After treatment 24 h urine Ca decreased distinctly in traditional Chinese medicine treatment group and combination treatment group(P < 0.05). The change was more significant in western medicine treatment group,compared respectively with traditional Chinese medicine treatment group and combination treatment group(P < 0.05); After traetment, the change in 24 h urine P and PTH in each group didno’t show any statistical significance(P>0.05); After treatment blood ALP increased distinctively in traditional Chinese medicine treatment group and combination treatment group(P < 0.05). The increase in Western medicine treatment group, compared respectively with traditional Chinese medicine treatment group and combination treatment group, was obvious and statistically significant(P < 0.05); After treatmentin pain points decreased distinctly in traditional Chinese medicine treatment group and combination treatment group(P < 0.05). The decrease in Western medicine treatment group, compared respectively with traditional Chinese medicine treatment group and combination treatment group, was statistically significant(P < 0.05).Conclusion: Artificial tiger bone powder can not only effectively increase the bone density of typ2 diabetic patients with early diabetic nephropathy and osteoporosis with, but also obviously improve the clinical symptoms of patients,such as lumbodorsal pain, lumbar genu soreness and weakness, walk with difticulty and combinatian of Chinese and western medicine treatment is clinically more effective.