Clinical Obersevation Of Shipi Powder In The Treatment Of Diabetic Nephropathy

ObjectiveThis study aims to observe the clinical efficacy of Shipi Powder for diabetic-nephropathy patients.MethodsChoose the spleen kidney Yang deficiency syndrome of inpatient and outpatient diabetes nephropathy patients a total of 90 cases, were randomly divided into treatment group and control group and combined group 30 cases each. Three groups of patients are strict diet and exercise therapy, conventional insulin to control blood sugar. The treatment group took Shipi Powder,one dose per day, once each morning and evening,200ml at a time;the control group took fosinopril, once per day, 10mg at a time;the combined group took 10mg fosinopril once per day and Shipi Powder, one dose per day,200ml each time both in the morning and evening. The course of treatment lasted for two months. The blood pressure level of all the groups was controlled to 130/80mmHg;those who couldn’t reach the standard, took extended release felodipine tablets. Those who had abnormal blood-lipid took Xuezhikang twice a day. The different clinical symptoms of patients before and after the treatment and the improvement of their physical signs were under observation;also their changes of Scr, BUN, CysC, usea nitrogen and 24 hour urine protein quantitation before and after, were monitored. By comparing the data, we could draw a conclusion on the efficacy of Shipi Powder in curing DN.Results1 In terms of improving clinical symptoms, the total effective rate was 90% in the treatment group, and 93.3% in the combined group, both were significantly higher than that of the control group, which was only 60% (P<0.05).2 The excretory rate of urine protein of the three groups all declined, the control group (P<0.05), the other two groups (P<0.01).But compared with the control group, the other two groups greatly surpassed the control group (P<0.05).But comparing the treatment group and the combined group showed no statistic significance (P>0.05).3 The BUN, Scr and CysC of the three groups all decreased after the treatment (P <0.01), which showed a significant statistic difference. But compared with the control group, the other two groups had a significantly different reduction (P<0.05).But comparing the treatment group and the combined group showed no statistic significance (P>0.05).4 The LDL-C, TC and TRIG of the three groups all decreased significantry(P<0. 01).After the treatment, the TC, LDL-C, TRIG level of the treatment group and the combined group had a statistic difference from that of the control group.ConclusionrApplication of Shipi Powder according to differentiation of symptoms can significantly decrease the excretory rate of urine protein ofdiabet ic-nephropathy patients. Shipi Powder can also improve clinical symptoms, it can ameliorate TC, LDL-C and TRIG quickly and manifestly, and ameliorate renal function. Shipi Powder is an effective cure for diabetic-nephropathy patients.