| Background:Neuroblastoma is one of the primary tumor present threat to the lives of children, the incidence rate, ranked third in the pediatric tumor, and there is an increasing trend. Meanwhile Neuroblastoma is also the most common peripheral nervous system malignancies in childhood.Under normal circumstances, the majority of children with neuroblastoma using traditional methods of treatment, including surgery, chemotherapy and radiotherapy. With the onset of neuroblastoma is closely related to the mother’s genes, proteins and signaling pathways, such as the study commenced people neuroblastoma tumor unique biological basis also have a better understanding. However, only surgery for early neuroblastoma effective, children still need to rely on advanced radiotherapy and chemotherapy treatments. On the other hand, are more side effects of chemotherapy, such as nausea, vomiting, weakness, bone marrow suppression, seriously affecting the quality of life of patients, many patients had to postpone chemotherapy, or simply refuse chemotherapy.Currently modern medical means of treatment of children with neuroblastoma, although relatively mature, but for children, particularly in the late survival rate of children with neuroblastoma tumors did not significantly improve. And surgery, chemotherapy and radiotherapy treatments, although these can be effectively treated or control tumor growth and metastasis, but the side effects associated with the growth and development and also affect the quality of life of children. Now combine the humanities and medicine, making people more concerned about the quality of life. Therefore, the quality of life is also included in the determination of efficacy.As a part of the Chinese traditional medicine, Chinese medicine in the treatment of advanced neuroblastoma has its unique advantages. It focuses on the relationship between global and local, through the combination of righting and evil, disease and syndrome differentiation of unity, in the clinical accumulated a wealth of experience. Many studies show that traditional Chinese medicine treatment of advanced neuroblastoma can reduce symptoms and improve quality of life having a good long-term effect.EORTC QLQ-C30 the EORTC(European Organization for Research on Treatment of Cancer) made life scale, including the core quality of life scale (EORTC QLQ-C30). QLQ-C30 is a common module, a total of 30 questions including five function subscale, three symptom subscale, six individual entries and an overall health assessment project. Available EORTC clinical scales to assess the quality of life of children with neuroblastoma tumors.Analysis:Professor Lv Ying summarizes theoretical academic thought and drug experience old Chinese Medcine doctor Li Ke, wo sorted out the idea of the seven points in academic medicine, in which an important part of the "qi monism " theory is academic thought. "Qi monism " theory theory is rooted in "Book of Changes ", " Yellow Emperor", Zhang, " Shang Han Lun", and a combination of the Qing Dynasty Zheng Qinan of academic thought and theory circular movement of the early Republic Peng Ziyi by recent clinical medicine old Li Ke 60 years of verification, Professor Lv Ying will be important academic thought and clinical practice of combining these physicians to construct the theoretical framework.Based on a stretch to explain a variety of diseases, into the ancient physicians doctrine, for conical treatment, and achieved good results.Children, compared with adults, from these has no serious internal injuries seven emotions (joy, anger, worry, anxiety, sadness, fear, surprise), diet weary, Six Exogenous (wind, cold, heat, wet, dry, fire), the same will get critical illness. From " Where are all sick of the qi from the disease " theory proposed by Li Ke. Therefore, whether adults or children, Six Exogenous, impassioned internal injuries, diet weary, gold edge of the injury, is the incentive of the disease, rather than the root cause. "Qi monism " theory that man’s birth, except the Father spermatocytes eggs, the Qi side of heaven and earth is the fundamental factor of adult students.Due to the strength of each individual endowment is biased in nature, in the growth process of human development, the contradictions will gradually focus on the end of the bias, when the amount accumulated to a certain extent, a qualitative change, especially in the yin interface, injury and internal organs, six qi-behaved disorder, it will show the corresponding disease like.Based on " Yang Qi, Yin forming", children suffering from neuroblastoma pathogenesis is due to congenital deficiency in Yuanyang endowment, forming cancer drug. The clinical manifestations of children, is what can be deduced invisible Qi led to the current symptoms, to guide clinical treatment medication.Who cured in Nanfang Hospital, professor Lv Ying According to Chinese medicine," Qi monism " doctrine of neuroblastoma pathogenesis of understanding, combined with years of clinical experience and clinical characteristics of neuroblastoma, summed neuroblastoma main pathogenesis (1, Yuanyang innate endowment, ice -volt yin; 2, JueYin a melting furnace Addict; 3, Yin can’t hold Yang, burnt hot outside; 4, Yangming volt hot; 5, budding ascending ineffective; 6, decifient of Qi, poor transport and six) and give prescriptions to cure.Objective6quality of life before and after using the EORTC QLQ-C30 and clinical symptom score rating scale was used to assess the QL before and after treatment, observation Qi monism under the guidance of traditional Chinese medicine with modern medical treatment quality of life for children with neuroblastoma.Method:Patients with neuroblastoma tumors incorporated in the south of the 22 cases the hospital. Initiation of therapy and self-control assessment in January. Evaluate the content of QLQ-C30 Life Scale and symptom scores table. Assessment include: QLQ-C30 Life Scale and symptom scores table. According to determine the clinical efficacy score. Data were analyzed by statistical software SPSS 19.0. Measurement data were normally distributed test of first, in line with normal distribution of data by the t test, do not meet the normal distribution of data using non-parametric tests. Analysis of count data using chi-square test. Test level a= 0.05.Results:QLQ-C30 quality of life table, the body, the role of the field, the cognitive domain, the total area of health, symptom subscale score, fatigue, nausea, vomiting, pain, shortness of breath, insomnia, loss of appetite, diarrhea module aspects improvement after treatment than those before treatment (P<0.05); and in the emotional sphere, the social sphere, constipation project scores while improving, but not statistically significant (P>0.05); economic difficulties, economic difficulties in treatment of patients after aggravating, but not statistically significant (P>0.05).Symptom score scale, the fatigue, shortness of breath and pain and symptom scores after changes before and after treatment, the differences were statistically significant (P<0.01); nausea and vomiting symptom scores before and after treatment, the difference was significant (P<0.05); anorexia, former constipation, diarrhea, insomnia, sweating symptom scores improved compared with the treatment, but before difference was not statistically significant (P<0.05).Efficacy of treatment after a month of treatment in clinical remission one month markedly 0 cases (0%), effective 16 cases (72.73%),6 cases (27.27%), worsening 0 cases (0%), clinical symptoms The total effective rate was 72.73% remission.Conclusion:Chinese medicine can effectively reduce symptoms and adverse reactions in patients with neuroblastoma, thereby improving the quality of life of patients. So, from the perspective of evaluating the quality of life for patients with neuroblastoma therapy, Chinese medicine treatment options significantly.Discuss:Medicine through treatment can significantly improve the patient’s fatigue weakness, nausea, vomiting, symptoms of pain, but overall the two results, anorexia, insomnia, sweating, constipation and diarrhea have improved somewhat, but not significantly improve, the reason is due to the patient’s yin this qi already scarce, despite a month of treatment, but it is difficult to correct this constitution; because the same symptoms related to the etiology and pathogenesis is not simple.Such as diarrhea, general awareness will recognize this as a symptom of the lack of lunar qi, Turkey Deficiency (or understood as spleen yang, but belong to the lunar spleen, on the moon, moisture rule, it is outside except spleen, also moisture inclusion, it can not be fully expressed by spleen Yang), corresponding to the decoction is the reason, but if we do not effect, you need to consider the fire is not adobe, mother (the mother earth for the fire), namely kidney the lack of true positive (so the medicine can be classified as the diarrhea Kidney failure), then the corresponding prescription was Sini decoction; but still useful clinical Sini decoction not effective,Based on " Qi monism " theory you need to consider Jue chill, bud ascending ineffective thus sinking, it will also have diarrhea, then the need to increase blindly Evodia Sini.From this, the complex clinical symptoms, which belong to the Yin of the Qi shortage situation difficult to reverse the change in the short term, but some of the symptoms, such as pain, treatment can break the ice back to the sun, nausea and vomiting can be reduced lung, gallbladder, against stomach Qi treatment, fatigue, shortness of breath can cure bud by solid protection, can be effectively alleviated, which can improve the quality of life of patients. |
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