Clinicai Value Of Ecolposcopy On Opportunistic Screening For Cervical Cancer

Objective:To investigate the clinical value of quality controlled eColposcopy on opportunistic screening for cervical cancer.Method:This study was conducted among 831 patients undergoing eColposcopy, TCT, HPV and histopathological examination from November,2013 to November,2014 in the second affiliated hospital of chongqing medical university. With pathological results as the gold standard, the sensitivity, specificity, positive and negative predictive value as well as the area under ROC curve of eColposcopy, TCT, HPV exclusive or combined screening for cervical cancer were analysed.Result:For lesions>CIN II, the specificity, the positive predictive value and the area under ROC curve of eColposcope were 96.30%、85.63% and 0.874, respectively, which were significantly higher than TCT, HPV exclusive or combined screening (P<0.05). The diagnosis sensitivity and the negative predictive value for lesions≥CIN II were improved with the combination of eColposcope, TCT and HPV, the sensitivity and the negative predictive value of eColposcope combined with HPV were 98.28%and 99.28%, which were significantly higher than the other methods exclusive or combined screening (P<0.05). Different types of cervical transformation zone had some impact on the result of eColposcope. The sensitivity, the specificity, the positive and negative predictive value as well as the area under ROC curve of eColposcope for type I cervical transformation zone were 92.71%、98.67%、94.68%、98.15%、0.957, respectively, which were significantly higher than type II and III cervical transformation zone(P<0.05).Conclusion:quality controlled eColposcope could be used in opportunistic screening for cervical cancer. Different cervical transformation zone has a certain influence on eColposcope, for the type Ⅱ and type Ⅱ cervical transformation zone, other screening methods such as TCT and HPV should be used.