Effects Of Tongbi Fang ET In Diabetic Patients With Lower Extremity Arteriosclerosis In Patients With Vascular Edothelial

Objective To observe the clinical effect of Tongbi prescription combined with lower extremity arteriosclerosis patients of diabetes, effects on vascular endothelin levels, and to explore its mechanism of action.Methods the randomized grouping, controlled trial design method.Select 200 cases accord with western medicine diagnosis of diabetic patients with lower extremity arteriosclerosis and TCM Qi Yin deficiency, blood stasis syndrome, were randomly divided into the treatment group of 120 cases, 80 cases in the control group. Regimen: control group: in the diabetes diet on static point of Shuxuetong injection 6ml(adding 100 ml normal saline), Qd.Treatment group: taking my courtyard Party Tongbi prescription based on the control group treatment(Spatholobus 15 g, astragalus root 30 g, red peony root 10 g, cassia twig, honeysuckle rattan, 10 g 15g 15 g, peach 10 g, dandelion, Rhizoma Chuanxiong, Radix Paeoniae Alba 15 g 10g Achyranthes bidentata 10 g, licorice 6G, 300ml) Decoction, one dose daily sooner or later, clothes. 15 days for a course of treatment, after 2 course of treatment, 3 days rest between treatments. To observe the clinical curative effect, two groups of patients with vascular endothelin level.Results the clinical curative effect of comparative efficiency: 2 courses of treatment group after treatment, the clinical effect was excellent in 40 cases, effective 69 cases, invalid 11 cases, the total efficiency of 90.8%. A control group of 80 cases, the clinical effective in 23 cases, effective 38 cases, invalid 19 cases, the total efficiency of 76.3%. The efficacy of the treatment group than in control group(P<0.05).The vascular endothelium of numerical: 2 courses of treatment group was compared before and after treatment(P<0.05), there is statistical significance; the treatment group after treatment(P<0.05), there was statistical significance. Treatment group and control group before treatment between two groups, P > 0.05, no statistical significance; the control group and the treatment group after treatment between the two groups(P<0.05), there was statistical significance.Comparison of the blood glucose, glycosylated hemoglobin effect: control group before and after treatment(P<0.05), there is statistical significance; the treatment group after treatment(P<0.05), there was statistical significance. Treatment group and control group before treatment between two groups, P > 0.05, no statistical significance; the treatment group and the control group after treatment, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin(P<0.05), compared with significant differences. The blood flow value comparison: comparison of before and after treatment(P<0.05), there is statistical significance; the treatment group after treatment(P<0.05), there was statistical significance. Treatment group and control group before treatment between two groups, P > 0.05, no statistical significance; the treatment group and the control group after treatment, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin(P<0.05), compared with significant differences.Conclusion Tongbi prescription has a good therapeutic effect in patients with lower limb atherosclerosis of diabetes, which can effectively improve endothelial function.