Ox-LDL、hs-CRP、MONO In The Clinical Significance Of CHD

Objective: Observation type oxidized low density lipoprotein(ox- LDL), high-sensitivity c-reactive protein(hs- CRP) and mononuclear cell count in stable angina pectoris(SAP) and in patients with acute myocardial infarction(AMI) predict the occurrence of diseases and its influence on prognosis. Method: From August 2013 to January 2015, we collected 56 patients who had acute STEMI as well as parallel coronary angiography and percutaneous coronary intervention and admitted to the Department of Cardiology of the First Affiliated Hospital of Fujian Medical University, including 24 males and 32 females. In the same period we collected 58 patients who had parallel coronary angiography and was finally diagnosed with stable coronary artery disease(SAP) 58 patients, including 24 males and 34 females. Meanwhile we collected 63 people who had excluded coronary heart disease in the physical examination center of our hospital, including 28 males and 35 females. We took STEMI as the group A, SAP as group B, people who had excluded coronary heart disease in the physical examination as the population group C, STEMI patients who had major complications within 72 h after the operations as group D, while patients who had no complications as Group E. For group A and group B, we took peripheral venous blood when they admitted to the hospitals, and conducted ox-LDL, hs-CRP and monocyte cytometry. The data of group C was obtained through retrospectively analysis and look up in the hospital medical center database. For group D and E, we extracted peripheral venous line within 72 hours after the operation on an empty stomach and conducted ox-LDL, hs-CRP and monocyte cytometry. At the same time we record the patients’ clinical data in details(including age, sex, smoking history, hypertension, diabetes history, etc.) as well as coronary angiography, PCI information including the lesion degree of coronary artery disease(chronic obstructive lesions, three lesions), the infarct-related artery(LM, LAD, LCX, RCA), etc., major complications after 3 days of operations(heart failure, arrhythmias, cardiogenic shock, stent Acute thrombosis). Results: The comparison of ox-LDL, hs-CRP and monocyte cytometry data in five groups: the data for A, B, D and E group were increased, but the increase in group A was more obvious than group B; the hematological indices in Group D was higher than group A while for group E it decreased compared with group A; the hematological index has no significant connect with MI area; the hs-CRP and monocyte data positively correlates with the number of diseased vessels, while the ox-LDL data doesn’t have obvious connect with the number of coronary arteries. Conclusion: ox-LDL, hs-CRP and monocytes can promote the occurrence of coronary heart disease, which are sound predictors for STEMI. For patients who has STEM, if the hs-CRP and monocyte cytometry are still in a relatively high level after operations, the srisk of major complications are also relatively higher.