A Study On Risk Factors About Type 2 Diabetes Patients With Comorbid Depression

Diabetes Mellitus(DM) is permanent chronic disease characterized by increasing levels of chronic blood glucose, while depression is mental and physical diseases with a significantly long-term low mood as its main clinical features. The related research on diabetes with comorbid depression has now become a hot topic both in China and abroad. As living standard of the public is rising and lifestyle is changing constantly, the number of diabetes patients shows an increasing trend year by year.The relevant study on diabetes with comorbid depression has already been involved internationally, but most study focuses on demographic data and a few biochemical indicators; this paper studies not only demographic data but also extends to multiple biochemical indicators, which supplements and facilitates the study on diabetes with comorbid depression.The author conducts a questionnaire survey regarding the collection of relevant clinical factors with patients diagnosed with type 2 diabetes in Comprehensive Department of Yan’an University Affiliated Hospital East Branch. By using the beck depression scale measurement(< 60 years old) or geriatric depression scale(60 or higher) on patients with geriatric depression, combined with clinical diagnosis, standard patients can be divided into two groups: type 2 diabetes mellitus with depression group(70 patients in experimental group) and simple type 2 diabetes mellitus group(80 people in control group). Results: 1. Age, gender and economic aspects between the control group and experimental group show no significant difference(p > 0.05); 2. Clear difference in educational level between the control group and experimental group has been identified(p < 0.05). What’s more, the lower educational level is, the more likely that patients would suffer depression. 3. Notable differences have been found in marital status between the control group and experimental group(p < 0.05). To be specific, divorced,widowed and single patients are more likely to be depressed; 4. The control group and experimental group display no significant differences(p > 0.05) in BMI, waist circumference, triglycerides and cholesterol, which indicates no direct link between depression and obesity; 5. Patients with the course of the disease lasting less than one year and more than 10 years suffer from the highest risk of depression, which is followed by course from 5 to 9 years, and 1-4 years is the lowest; 6. There is no direct link between smoking and depression(χ2=0.14,p>0.05); 7. The control group and experimental group show obvious variance on chi-square check of family history(χ2=10.44,p<0.01). Patients with no family history are more likely to suffer from depression than patients with a family history of depression; 8. there is significant difference(p < 0.05) in blood sugar and blood cortisol between the control and experimental groups, which explains that depression affects blood glucose control and makes the hypothalamus- pituitary- adrenal axis dysfunctional; 9. Through the Logisti regression analysis, the author found that high risk factors of patients with type 2 diabetes includes marital status, duration, family history, blood sugar and blood cortisol.Conclusion: 1. Depression is more likely occur among divorced, widowed, and single patients; 2. Patients with the course of the disease under 1 year and more than 10 years of patients are more likely to suffer from depression; 3. Patients with no family history of depression have higher possibilities to be depressed than patients with a family history; 4.Fasting blood glucose, 2 hour postprandial blood glucose and glycosylated hemoglobin of type 2 diabetes patients with comorbid depression are higher than non-comorbid depressed patients; 5. Blood cortisol of type 2 diabetes patients with comorbid depression were higher than non-comorbid depression at eight o ’clock, at four o ’clock in the afternoon and zero. 6. Risk factors for type 2 diabetes patients with depression include educational level, duration, family history, blood sugar and blood cortisol.Through the above-mentioned research, risk factors of type 2 diabetes mellitus with comorbid depression are identified as marital status, duration, family history, blood sugar and blood cortisol. The discovery of these risk factors would lay a necessary foundation for the prevention and treatment of type 2 diabetes patients with depression.