The Study Of The Difference Of IMA Between Cardiac And Non-cardiac Chest Pain Patients

Objective: This paper discusses the difference of ischemia modified albumin(IMA) between cardiac and non-cardiac chest pain patients. We analyses the clinical diagnostic value of IMA in early myocardial ischemia.Method: According to the chest pain time, the serum specimens were collected from 72 cardiac and 34 non-cardiac chest pain patients were detected, which samples were obtained at when they arrived emergency department immediately(within 3 hours of onset of chest pain), 6 hours, 24 hours after they are suffered chest pain. And serum IMA and c Tn I levels were observed respectively. To observe the difference of IMA between cardiac and non-cardiac chest pain patients and the level trend of IMA at the same time. Then we draw the ROC curve, try to determine the cutoff value of albumin-cobalt binding(ACB) of early screening cardiac chest pain,. Try to compare the clinical diagnostic value of IMA and c Tnl in early diagnosis of myocardial ischemia.Results: IMA levels in patients with cardiac chest pain group when they immediately arrived at emergency department(within 3 hours of chest pain) and 6 hours are 71.3U/ml and 75.7U/ml respectively, higher than non-cardiac chest pain group and the healthy control group(P<0.01). Though dynamic observation, the IMA levels in patients with cardiac chest pain group could raise obviously in 3 hours after chest pain happened, higher after 6 hours, but drop on normal level within 24 hours. The area under ROC curve of IMA was 0.853, while the cutoff level is taken 68.30 u /ml, with a sensitivity of 80.67% and a specificity of 79.4%. In early time of cardiac chest pain(less than 3 hours), the IMA diagnosis has higher sensitivity than c Tnl, which were 84.7% and 65.26%. The sensitivity of combined could arrive at 90.27%.Conclusion: The IMA could identify the cardiac and non-cardiac chest pain chestpain at the early time.