The Relationship Between Thyroid Stimulating Hormone And Homocysteine Of Type 2 Diabetic Patients

ObjectiveStudy the relationship between thyroid stimulating hormone(TSH) and homocysteine(HCY) in serum of type 2 diabetic(T2DM)patients.MethodsCollect 200 patients with T2 DM who hospitalized in Department of Endocrinology in the Second Affiliated Hospital of Ningxia Medical University as diabetic groups. Their average age is(55±15). And 88 patients are male, and 112 patients are female 112. Divide 200 T2 DM patients into three groups according to the level of TSH, that is the group of TSH(UIu/m L) with 33 cases < 0.3, the group of TSH with 132 cases which≥0.3 and ≤5.5, the group of TSH with 35 cases which>5.5 and healthy control group with 50 cases respectively. Collect medical center 50 healthy subjects whoes average age is(50.61±9.47) in Second Affiliated Hospital of Ningxia Medical University as the control group so that HCY and other index are tested and some related analysis are carried out.Results 1. The level of HCY in T2 DM is higher than that of normal people(P<0.05). 2. There difference among the HCYand TSH of those three groups has statistical meaning. And TSH levels and HCY levels are positively correlated(P <0.05). 3. There is positive correlation between the HCY as well as T2 DM and its complications.(P<0.05). 4. T2 DM patients’ HCY cortisol and, Hb A1 c,TG,TC,LDL-C are positively correlated(P <0.05) and was negatively correlated with high-density lipoprotein(HDL-C)(P <0.05).Conclusion1. TSH changes in the serum of Type —2 diabetes patients serum are positively correlated to HCY and vascular complications. And tips are given to Type-2 diabetes patient whose symptom is not associated with thyroid disease that if the thyroid hormone state is normal, the risk of vascular complications occurred as TSH levels increased. TSH may be a risk factor for Type-2 diabetes patients with vascular disease.2. TSH changes in the serum of Type-2 diabetes patients is related to glucose and lipid metabolism, which indicates that TSH Changes and Blood Glucose, Lipid, HCY reinforce each other. Thus, monitoring TSH and HCY is helpful to recognize the condition and prognosis of Type-2 diabetes.