Effect Observation Of Tramadol Combined Sufentanil In Postoperative Intravenous Analgesia For Gerontal Patient

Objectives:In this study, using the patient controlled analgesia(patient controlled analgesia,PCA) method, and the analysis of the clinical and immunological parameters of indicators to evaluate tramadol combined with sufentanil for postoperative intravenous analgesia in elderly patients. Methods:Select open cholecystectomy under general anesthesia, 90 cases of elderly patients aged 65~80 years old, ASAâ… ~â…¡ grade, were randomly divided into three groups : S group, SD group, SQ group, 30 cases in each group. All patients underwent general anesthesia, analgesia before the end of surgery received continuous intravenous analgesia pump, continuous infusion of 2ml / h, a loading dose of 2ml, PCA is 1ml, the lock time is 15 min. Three groups of analgesia formula : S Group: sufentanil 3ug/kg+ palonosetron 0.25mg; SD group : sufentanil 2ug / kg + dezocine 0.2mg / kg + palonosetron 0.25mg; SQ Group: sufentanil 2ug / kg + tramadol 10 mg/kg + palonosetron 0.25mg; each group plus saline to 100 ml. Were observed 30 minutes before anesthesia, surgery completed immediately, after 24 hours, after 72 hours 4 time points in patients with plasma interleukin-6(IL-6), interleukin-10(IL-10) levels, recorded and compared 2,4,8,24,48 hours after five time points in patients with pain scores( visual analogue scale, VAS), sedation score(Ramsay) and adverse reactions. Results:In the pain score, VAS of three groups was no significant difference at each time point(P> 0.05), after the S group and SD group of 2,4,8-hour sedation scores were higher than the SQ group(P<0.05), and the S group and SD group the incidence of adverse reactions higher than SQ group(P<0.05), SD group than S group(P <0.05). Three groups of patients immediate surgery IL-6, IL-10 levels before and 30 minutes of anesthesia were significantly higher compared to(P <0.05), after 24 hours began to decline, but still higher than after 72 hours before surgery, and among the three groups in the same time points IL-6 and IL-10 had no significant difference(P> 0.05). Conclusion:Tramadol combined with sufentanil for postoperative analgesia in elderly patients is safe, effective analgesic and sedative effects of satisfaction, a low incidence of adverse reactions.