The Change Of The Level Of Plasma D-dimers In Preeclampsia Patients And Its Correlation With Blood Fat

Background: Pre-Eclampsia(PE) is one state of gestational hypertension with the main pathological change of arteriole spasm around the body. Its clinical feature includes hypertension, proteinuria, edema and multi-organic damage which disappear after delivery. PE seriously influences the health of maternal-child and is the main reason of fetal growth retardation and pregnant and perinatal death. Timely and accurate predict and early interventions have important implications for PE. However, current signs have some defect in accurate predict in PE.Objective: To explore the predictive value of D-dimer levels and its correlation with blood fat by comparing the D-dimer levels and its correlation with blood fat between patients of PE and normal pregnant women.Methods: The clinical data of 88 PE patients and 43 normal pregnant women were divided into mild PE group(n=32), severe PE group(n=56) and normal pregnant women group(n=43) by the standard of Diagnosis and treatment Guideline on Hypertensive Disorders in Pregnancy(2012). All of the patients were without other complications. The plasma D-dimers, TC, TG and coagulation indicators of all the subjects are measured for comparison and analysis between all the groups.Results: The level of D-dimers of PE was markedly higher than that of normal pregnant women group(P<0.05), and it was obviously higher in severe PE than that in mild PE(P<0.05). The area under curve of D-dimer for diagnosis of PE was 0.901(95%, CI: 0.729, 1). The predictive sensitivity and specificity were 0.962 and 0.714, respectively, at the optimal threshold of 0.685ug/ml. The level of the D-dimers in PE patients increased along with the level of SBP and DBP, and it was in positive correlation with DBP(P<0.01). Besides, the level of D-dimers was positively correlated with the level of TG and TC(P<0.05 or P<0.01) and also positive correlated with the parameters of renal dysfunction(P<0.05 or P<0.01). In normal pregnant women, no relationship in above indicators was observed(P>0.05).Conclusion: The level of plasma D-dimers is closely related to the aggravation of PE and positivly related to blood fat. Therefore, the level of plasma D-dimers is a good index to assess the condition of PE.