Correlation Between Blood Pressure And Postpartum Proteinuria In Patients With Preeclampsia

Objective:This thesis aims to study the relationship between the prenatal blood pressure and the proteinuria at 3 months postpartum of preeclampsia(PE)patients.Methods:A total of 218 cases of PE patients were collected retrospectively from January,2016 to January,2020.The end-point of the study was positive urine protein at 3 months postpartum.Binary logistic regression was used to analyze the correlation between prenatal blood pressure and postpartum proteinuria.Results:According to the prenatal systolic blood pressure(SBP)and diastolic blood pressure(DBP)tertiles,the patients were divided into three groups: SBP: Group 1(112-149 mm Hg,n=72),Group 2(150-167 mm Hg,n=73),Group 3(168-235 mm Hg,n=73);DBP: Group 1(65-93 mm Hg,n=72),Group 2(94-104 mm Hg,n=73),Group 3(105-145 mm Hg,n=73).After 3 months of postpartum follow-up,49(24.1%)PE patients were positive for urine protein at 3 months postpartum.According to the binary logistic regression analysis,after adjusting for variables such as DBP,chronic hypertension,days of pregnancy,PE stage,intrauterine growth restriction,age,glomerular filtration rate,SBP and total cholesterol were independent risk factors for proteinuria at 3 months postpartum(SBP: OR: 1.054,95% CI: 1.023-1.087,P = 0.001;total cholesterol: OR: 1.317,95% CI: 1.080-1.607,P = 0.007).For every 1mm Hg increase in SBP,the incidence of proteinuria increased by 5.4% 3 months after delivery.Conclusion: Blood pressure is related to proteinuria in PE patients 3 months after delivery.The increase of SBP is an independent risk factor for proteinuria in PE patients at 3 months postpartum.