The Clinical Observation Of Warfarin In Combination With Xue Fu Zhu Yu Tablets Applied To Anticoagulation Therapy After Deep Venous Thrombosis Interventional Operation

Objective:To study the clinical efficacy of Warfarin in combination with Xue fu zhu yu tablets applied to continous anticoagulant therapy of deep venous thrombosis and its influence on the coagulation index. The Clinical efficacy of combined traditional Chinese with western medicine for anticoagulation therapy was discussed preliminarily to compare single Warfarin group with combination drug group on their anticoagulant efficacy and adverse reaction.Methods:65 cases after deep venous thrombosis interventional operation meeting inclusion criterion were included. They were randomly divided into treatment group using Warfarin combining with Xue fu zhu yu tablets(n=32) and control group using Warfarin(n=33). Treatment group: Using the basic treatment, Xue fu zhu yu tablets and Warfarin. Warfarin was given before discharging from hospital. The dose of Warfarin was adjusted from initial dose of 2.5mg/d according to INR(controlled between 2 and 3).The dose of Xue fu zhu yu tablets was 6 tabletss each time,2 times each day. 30 patients were followed up to 2 months after discharging from hospital. Control group: Using the basic treatment and Warfarin. Warfarin was given before discharging from hospital. The dose of Warfarin was adjusted from initial dose of 2.5mg/d according to INR(controlled between 2 and 3). 30 patients were followed up to 2 months after discharging from hospital. The difference of the basic data such as age, gender and duration of disease between the two groups were not statistically significant(P>0.05), which show the two groups were comparable. The efficacy of 30 days and 60 days after treatment of two groups were compared at follow-up.Coagulation function index,symptoms improvement and adverse reactions of 6 times follow-up results(the 3rd day, the 7th day, the 14 th day, the 30 th day, the 45 th day, the 60 th day, respectively)were compared. The patients’ number of change at Warfarin’s dose and the average dose of Warfarin were compared. The efficacy and the possible existing mechanism of Warfarin in combination with Xue fu zhu yu tablets applied to continuous anticoagulation therapy after deep venous thrombosis interventional operation were proved statistically.Results:(1) By comparing the blood coagulation index of follow-up results of two groups(P<0.05), It showed that treatment group was superior to control group in the anticoagulation efficacy and stability.(2) By comparing the efficacy of 2-month follow-up results of two groups, the total effective rate in treatment group and control group was 87% and 70% respectively 30 days after treatment and 97% and 80% respectively 60 days after treatment, which shows significant differences statistically(P<0.05) and the efficacy of the treatment group being superior to the control group.(3) By comparing the adverse reactions of two groups: Gingival bleeding(1 case) and subcutaneous hemorrhage(1 case) occurred in treatment group whereas gingival bleeding(2 case), subcutaneous hemorrhage(1 case),stool occult blood(1 case) and urinary occult blood(1 case) occurred in control group. The difference at the incidence rate of adverse reaction between the two groups were significant.(4) The patients’ number of change at Warfarin’s dose and the average dose of Warfarin at follow-up were compared between the two groups.The treatment group were lower than those in the control group.Conclusions:The efficacy of Warfarin were influenced easily by patient’s autogenesis, interactions between food and drugs, and living habits, so that the instability of Warfarin’s anticoagulation effect for and the incidence rate of adverse reaction improved.(1)Our research shows the Clinical efficacy of Warfarin in combination with Xue fu zhu yu tablets applied to continous anticoagulant therapy of deep venous thrombosis was better than single Warfarin, more stable as well as the low rate of adverse reaction occurrence.(2) The clinical observation of applying anticoagulation combined use of traditional Chinese and western medicine and thought of stage differentiation to deep venous thrombosis continous anticoagulant therapy. Applying combined traditional Chinese with western medicine for anticoagulation therapy at thought of differing stage and syndrome differentiation was worth studying and researching on clinical anticoagulation therapy furthermore.