| Purpose To interfere with the occurrence of chronic renal failure and heart damage, guided by the Traditional Chinese Medicine(TCM) theory of coordination between the heart and kidney, some effective and feasible methods of treating chronic renal-cardiac syndrome are explored by observing clinical efficacy in treating chronic renal-cardiac syndrome by using the coordinating heart-kidney prescription.Method According to experimental design standards, 60 cases of eligible patients with chronic renal-cardiac syndrome were selected, they were randomly divided into a control group and a treatment group, 30 patients in each group. The control group consists of patients treated with conventional western medicine together with shenshuaining capsule. On the other hand, the treatment group were those treated with conventional western medicine and the coordinating heart-kidney prescription. 3 months later,the symptoms and serum creatinine(Scr), blood urea nitrogen(BUN), s-adenosine homocysteine(SAH), fibroblast growth factor 23(FGF-23), c-reactive protein(CRP), left ventricular end-diastolic dimension(LVEDD) were observed in each group. These indicators would be compared with those prior to the treatment, and the curative effect of two groups after treatment of different methods. The results of the experiment would be processed by statistical software SPSS17.0.Recorded(1)During the clinical observation, 30 patients after the treatment with the coordinating heart-kidney prescription, compared with the control group, there was a significant difference(P<0.05) in the main clinical symptoms such as: lassitude, lumbar debility, cold limbs, limb edema, chest tightness, shortness of breath, palpitations, insomnia, eat less anorexia, nausea and vomiting. The main clinical symptoms after treatment in treatment group have improved more obviously, which demonstrated that the therapeutic principles should take traffic heart and kidney as the primary, assisted with wenyang and diuresis, promoting blood circulation and drain turbidity. By focusing on the pathogenesis of chronic renal heart syndrome, to improve the the patients clinical symptoms significantly.(2)Treatment group BUN and Scr compared before and after treatment has difference(P<0.05); control group BUN, Scr before and after treatment compared with difference(P<0.05). Two after treatment between the two groups, there are statistical differences in the treatment group and control group(P<0.05). After the adoption coordinating heart and kidney prescription, patients’ renal function have been improved significantly, compared with the control group.(3)In the treatment group, plasma SAH, FGF-23 levels has difference before and after treatment(P<0.05). There are differences in contrast between the treatment group and the control group after treatment(P<0.05). Because of high SAH and FGF-23 are listed within the TCM phlegm, congestion category. The principle of treatment takes traffic heart and kidney as the primary, assisted with wenyang and diuresis, promoting blood circulation and drain turbidity, the prescription can reduce the levels of SAH and FGF-23 in plasma. It has significant differences compared with the control group.(4)Before and after the treatment, hs-CRP level was recorded in both groups, with a difference(P<0.05). Also, it has statistica difference between two groups after treatment(P<0.05).Modern pharmacological study found that many of the traditional Chinese medicine can make CRP levels declined in patients,and improve the patient’s micro-inflammatory state.(5)In the study, the two groups show an elevated level of hemoglobin in varying degrees after treatment. There was some improvement in symptoms of anemia. But the difference was not statistically significant(P>0.05). This may be relevant to short interval of time in treatment.(6)In the treatment group, heart LVEDD has difference before and after treatment(P<0.05). There are differences in contrast between two groups after treatment(P<0.05). It proved left ventricular end-diastolic diameter can be reduced by the coordinating heart kidney prescription, improve heart structure.Conclusion Guided by the TCM theory of coordination between the heart and kidney, the coordinating heart-kidney prescription was applied in the intervention of the treatment of chronic renal-cardiac syndrome, and the clinical symptoms have been obviously improved, particularly effective in terms of reduction of the urea nitrogen, serum creatinine, decreasing the levels of the SAH, FGF-23 and inflammation factor CRP, reduce heart left ventricular end-diastolic diameter. The treatment is significantly better than other conventional treatment in improving renal function and preventing of cardiac abnormalities. |
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