The Incidence Of Cardiovascular Events And Its Related Risk Factors In Diabetes And Hypertension

Objectives To observe the incidence of cardiovascular events and its related risk factors in diabetes and hypertension.Methods In 2006~2007, a total of 101510 patients, excluding the 3669 patients with a history of cardiovascular and cerebrovascular events, lack of relevant research data in3926 cases.A total of 3173 patients with diabetes, 35161 patients with hypertension, 5261 patients with both hypertension and diabetes, and 50320 cases without hypertension and diabetes from the Kai Luan study cohort were enrolled. Incidence of cadiocerebral vascular events(myocardial infarction, cerebral infarction and cerebral hemorrhage) and all-cause mortality events was obtained during follow-up. Multivariable Cox proportional hazards regression models was used to assess relative risk of cardiovascular and allcause mortality events.Results Compared to diabetes group, the proportion of male,blood pressure, body mass index(BMI), creatinine, high density lipoprotein cholesterol(HDL-C) and uric acid(UA)were higher, but the average levels of total cholesterol, triglyceride(TG), fasting blood glucose(FBG) and high sensitivity C-reactive protein(hs CRP) were lower in hypertension group(P<0.05). The mean follow-up time was 48 months. There were 1863 cardiovascular events recorded during the follow up period. In cases without hypertension and diabetes, the incidence rates of cardiovascular events, myocardial infarction, cerebral hemorrhage, cerebral infarction, and all-cause mortality were 0.87%,0.19%, 0.49%, 0.20%, 1.09%; In diabetes were 3.18%, 0.88%, 0.38%, 1.95% and 2.9%;in the hypertensives were 2.99%,0.55%, 0.74%, 1.77% and 2.20% and in patients with both hypertension and diabetes were 5.11%, 1.27%, 3.19%, 0.78%, 3.78%, respectively(all P<0.05). After adjusted for other traditional cardiovascular risk factors, compared with subjects without hypertension and diabetes,the RR(95%CI) in diabetes, hypertensives and diabetes combined hypertensives were 2.773(2.225~3.455),2.571(2.290~2.887), 3.975(3.390~4.662)respectively for cardiovascular events; and those were3.040(1.976~4.677), 1.965(1.528~2.528), 3.797(2.740~5.261) for myocardial infarction, 3.026(2.281~4.015), 2.629(2.256~3.063), 4.383(3.569~5.383)for cerebral infarction, 1.679(0.919~3.068), 3.146(2.470~4.007), 3.088(2.104~4.531)for cerebral hemorrhage; and 1.988(1.584~2.494),1.462(1.305~1.639), 2.411(2.035~2.856)for all-cause mortality(Including diabetes group and cerebral hemorrhage events without statistical significance the control group(P > 0.05), and the others all P < 0.05).Conclusion In Kai Luan cohort, Diabetes and hypertension are independent risk factors for cardiovascular events.Compared with diabetes, the incidence of myocardial infarction and all-cause mortality events were higer, while the incidence of cerebral hemorrhage was lower than than in hypertension.