The Research For Safety And Effectiveness Of Yaotongning Capsule In The Treatment Of LOA

Objectives Evaluation of Yaotong ning capsule treating lumbar osteoarthritis(cold dampness stasis resistance) pain, function improvement and efficient and at the same time evaluating the safety of clinical application of Yaotong ning capsule.Methods The108 patients collected in the li rheumatism lead and the orthopaedics of north China university of science and technology affiliated hospital,divided into according to the principle of a double-blind, randomized, controlled the high dose group, low dose group and the control group, 36 cases in each group, high dose group was given Yaotong ning capsule 6 / day, low dose group was given Yaotong ning capsule 4 / day, the control group given pain Bitong ning capsule, 2pill,2 / day, a course of 4 weeks. By using visual analog pain score(VAS) and analgesic effect time, O swestry disability index(ODI) and its curative effect evaluation of its effectiveness; The rate of adverse reactions, electrocardiogram and laboratory test indexes such as evaluation of its safety. By application of Excel in data entry, and using SPSS17.0 to analysis. This research ethics committee approval, all patients signed the informed consent.Results 1 effectiveness:before treatment, three groups of patients with general information and no difference, comparable, after treatment, the high dose group, low dose group and the control group patients resting pain VAS values are falling, followed by 2.45±1.17、3.41±1.08、3.58±1.51,high dose group is better than the other two groups, The other two groups of the same;After treatment, the high dose group, low dose group and the control group patients pain VAS values are falling, followed by 2.38±1.26、3.38±1.09、3.53±1.53, high dose group is better than the other two groups, The other two groups with no difference;After treatment, the high dose group, low dose group and the control group patients ODI are falling, followed by 9.46±3.40、12.61±3.34、12.86±4.63,high dose group is better than the other two groups, The other two groups with no difference;High dose group, low dose group and the control group resting pain analgesic effect time of 7.37±4.34、10.12±4.21、8.71±2.95,high dose group and the control group is better than the low dose group, high dose group compared with control group no difference;High dose group, low dose group and control group activities pain analgesic effect time of 7.71±4.48、10.27±3.38、9.46±3.84,high dose group is better than the other two groups,The other two groups with no difference;Over all effectiveness, high dose group(86%) is better than the low dose group(78%) and the control group(75%). 2 Security aspects, three groups were no serious adverse events. The vital signs and examination has no difference before and after the treatment, laboratory test, high dose group of mild 3 cases, low dose group of slight anomaly 3 cases and control group 4 cases were slightly abnormal, and causality are "suspect".Conclusions Yaotong ning capsule can significantly improve patients with lumbar osteoarthritis pain VAS scores, analgesic effect time and ODI score, high efficient and low incidence of adverse reactions, the treatment of lumbar osteoarthritis(cold dampness stasis resistance) has a good advantage.