| Objective: Based on the clinical study of Shengmaiyangxin Ke Li, we are aimed to discuss the effect on the left ventricular diastolic function, Clinical symptoms and laboratory tests of the patients with "deficiency of both Qi and Yin, blood and water stagnation syndrome" diastolic heart failure(DHF) and to evaluate the curative effect and safety of the use of it in the patients with “deficiency of both Qi and Yin, blood and water stagnation syndrome” diastolic heart failure(DHF).Then we can provide an objective basis for its clinical application.Method: 60 patients with “deficiency of both Qi and Yin, blood and water stagnation syndrome” DHF were randomly divided into 30 cases in the treatment group and the other 30 cases in the control group. The treatment group was treated with shengmaiyangxin keli and conventional western medicine.The control group are treated with conventional western medicine only;4 weeks after the treatment, changes of the two groups were observed before and after treatment: symptom integral and comprehensive curative effect of traditional Chinese medicine, Minnesota life quality score, 6 minutes walk test, heart function classification, BNP and echocardiographic test.Result: 1.TCM symptom integral and comprehensive curative effect: in this trial TCM symptom integral of the two groups are both greatly improved before and after treatment(P<0.05). Statistical analysis result of the symptom integral after treatment of the two groups is P<0.05,meaning that the result has statistical differences. The comprehensive curative effects of treatment group and control group are 96.6% and 93.3% respectively.The effective rate of the treatment group is 21 persons(70%)markedly effectively,8 persons(26.6%) effectively,1 persons(3.3%) ineffectively. And in the other group were cured 12 persons(40%), effective in 16 persons(53.3%), ineffective in 2 persons(6.6%).The two groups exist significant statistical difference(P<0.05).The effectiveness on every TCM symptom is that the two groups can improve all the symptoms, but the trail group is more effective than the other group on the whole symptom excluding chest tightness(P<0.05).2.The effect on Minnesota life quality score of heart failure patients: the two groups both can improve Minnesota life quality score(P<0.05),but the treatment group can improve life quality better than the control group(P<0.01).3.The influence on 6 minutes walk test: the walking distance of the trail group and control group after treatment are 431.83±19.76m、368.83±18.87 m respectively。The two treatments can extend the distance bothly(P<0.05).And there is significant statistical differrence(P<0.01) between the two groups by t-test, meaning that the trail group is more effective than the control group.4. The heart function classification effect(NYHA): the result of assessment of patients ’ heart function classification is that heart function classification were both improved in the two groups: total effective rate, markedly effectiveness,effectiveness, ineffective- ess of the treatment group are 83.3%, 8(26.6%), 17(56.6%), 5(16.6%) respectively and that of control group are 80%, 7(23.3%), 17(56.6%), 6(20%) respectively. But statistical result shows that there is no significant statistical difference between the two groups(P>0.05).5.Effects on BNP: After treatment the BNP plasma level of the treatment group and control group is 40.90±12.90pg/ml,104.23±21.54 pg/ml respectively. Nonparametric test result shows that the two treatments both can significantly decrease BNP plasma level(P<0.05), and it exist statistical difference between the two groups(P<0.01).6. Effects on echocardiographic test: Nonparametric test results shows That the two groups can both decrease LAVI and E/E’greatly(P<0.05),and the two groups are statistically different on E/E’(P<0.01). However,there is no statistical difference between the two groups on LAVI(P>0.05).Conclusion: The clinical results suggest that the treatment group and the control group in patients with diastolic heart failure can improve the curative indicators, but thetreatment group were able to further reduce the signs and alleviate symptoms, improve heart function, increase exercise tolerance and quality of life. It reveals that based on the western tips plus Shengmaiyangxin Ke Li in patients with diastolic heart failure is more effective than western medicine alone. It explained the use of combined treatment of western medicine and Shengmaiyangxin Ke Li in diastolic heart failure is curative, safe, reliable, worthy of clinical reference and further promotion. |
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