| Objective:To observe the conditions of oxidative stress after stroke onset via the ox-LDL level in patients with acute ischemic stroke.Methods:One hundred and eight-six patients hospitalized and diagnosed as acute ischemic stroke in Yanbian University Affiliated Hospital from February 2014 to May 2014 were enrolled, including 128 male patients and 58 female patients at average age of 63.00±10.91 years old. The ox-LDL test and relative factors were analyzed and studied (including SSS-TOAST, NIHSS, gender, age, ethic groups, body mass index (BMI), smoking, drinking, exercises,atherosclerosis,CRP, LDL, TC, TG, HDL, HBG, WBC, PLG, ALT, AST, Cr, BUN, UA, FBS and Hcy).The correlation between ox-LDL in patients with acute ischemic stroke and types of strokes; the correlation between nervous system NIHSS score and UA, CRP, DBIL and ox-LDL; and the correlation between various risk factors and ox-LDL in patients with acute ischemic stroke were evaluated using EXECL-created database and SPSS 19.0 software.Results:1.Proportion of SSS-TOAST of various types of strokes among patients with ischemic stroke:The category of large-artery atherosclerosis consists of 71 patients (38.2%), cardiogenic embolism of 10 patients (5.4%), small artery occlusion of 48 patients (25.8%),5 patients (2.7%) with other etiology, and 52 patients (27.9%) with uncertain etiology.2.The correlation between ox-LDL in patients with acute ischemic stroke and types of strokes:There were differences among the large-artery atherosclerosis (61.60±7.264), small artery occlusion (54.84±14.344) and patients with uncertain etiology (48.24±16.043) while there were differences between ox-LDL in cardiogenic embolism (58.93±6.704) and patients with uncertain etiology (48.24±16.043).3.Correlation between nervous system NIHSS score and UA, CRP, DBIL and ox-LDL:NIHSS score was classified as three groups, including mild (<4 points), medium (4-15 points) and sever (>15 points) groups. CRP had no differences between mild (0.21±0.224) and medium (10.16±17.941) groups and had no differences among mild, medium and severe (47.50±83.958) groups. UA had differences among mild (215.45±50.856), medium (273.54±96.130) and severe (349.56±120.516) groups. Ox-LDL had differences among mild (38.89±18.098), medium (58.29±7.712) and severe (64.72±4.274) groups. DBIL had differences between mild (4.83±1.920) and severe (8.10±6.941) groups.4.Correlation between ox-LDL and different genders, ethnic groups, smokers, drinkers,excises and atherosclerosis:There were no differences between 128 male patients (55.07±13.376) and 58 female patients (57.20±13.08) and there were also no differences between 79 smokers (55.41 ±13.091) and 107 non-smokers (55.98±13.484), as well as 79 drinkers (55.83±13.06)and 107 non-drinkers (55.66±13.511); 131 patient doing exercises (54.57±14.686) and 55 patients not doing exercise (58.50±8.627);112 atherosclerosis (56.03±12.259) and 74 no atherosclerosis (55.28±14.781);75 patient belong to the Korean-Chinese nationality (56.02±13.365) and 105 patients belong to the Han nationality (55.34±13.574);.5.Rank correlation analysis:The rank correlation coefficients of ox-LDL in different age and BMI were 0.085 and 0.034 respectively, without statistical significance. Rank correlation analysis in different lab indexes, including CRP, LDL, TC, TG, HDL, HBG, WBC, PLG, ALT, AST, Cr, BUN, UA, FBS and Hcy, its coefficients were 0.424,0.142,0.120,-0.049,0.059,0.032,0.156,-0.036,0.074,0.113,-0.061,0.097,-0.009,-0.009 and-0.049, respectively, of which ox-LDL with CRP and WBC’s correlation coefficients had statistical significance6.Multiple linear regression (MLR) analysis:MLR analysis was carried out for CRP, WBC and exercises. CRP’s regression coefficient was 0.050, P<0.05, with statistical significance. It indicates that the more the CRP, the ox-LDL level will be higher. The regression coefficient of exercises was-4.131, P=0.050, with statistical significance. It indicated that ox-LDL level in exercises was lower than that of no exercises. WBC’s regression coefficient was 0.119, P>0.05, without statistical significance.Conclusion:1.ox-LDL is closely related to the Large-artery atherosclerosis of acute ischemic stroke.2. ox-LDL is closely related to acute ischemic stroke.3.Exercises and CRP are independent predictive factors for ox-LDL. |
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