Oral Contraceptive Pill Pretreatment Improves IVF/ICSI Outcomes Of PCOS Patients

ObjectiveTo evaluate different oral contraceptive pill (OCP) pretreatment associated differential in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) outcomes of polycystic ovary syndrome (PCOS) patients and explore enhanced hormonal balance induced by the pretreatment.MethodsThis retrospective study included500PCOS women and565normal ovulating counterparts undergoing IVF/ICSI. The PCOS patients were divided into three groups based on the OCP pretreatment regimens:non-OCP (without OCP pretreatment), unsuccessive OCP (the period of successive pretreatment≤2months) and successive OCP (the period of successive pretreatment≥3months) groups. Comprehensive hormonal and ultra-sonographic assessments were performed before or after IVF pretreatment. All the collected data was summarized as chart by using statistical analysis.ResultsPCOS patients with significant endocrine disorders had reduced implantation and pregnancy rates and increased miscarriage rate. Successive, not unsuccessive OCP pretreatment, significantly improved the implantation and pregnancy rates, and reduced the incidence of monotocous small-for-gestational age infants, which was accompanied by remarkably decreased hyperandrogenism and antral follicles.ConclusionPCOS is an independent risk factor for poor IVF outcome. Successive, not unsuccessive, OCP cyclical pretreatment could improve pregnancy outcome of PCOS patients, associated with reduction of hyperandrogenism and antral follicle excess.