| Purposes Through chromosomal karyotype analysis of infertile people,the detection rate of chromosomal polymorphism in infertile people were calculated.Taking infertile couples treated with IVF/ICSI-ET for reaserch objects,through comprasion and analysis of pregnancy outcomes in infertile couples with or without chromosomal polymorphism to discuss the effect of chromosomal polymorphism on IVF/ISCI-ET pregnancy outcome in infertile patients.Method By reviewing the electronic medical record system and follow-up records of the Reproductive Center of the Tianjin Central Obstetrics and Gynecology Hospital,the detailed medical records of patients receiving IVF/ICSI-ET treatment from January 2015 to December 2017 were obtained.Related indicators were statistically analyzed by IBM-SPSS v.23.0 software.First,calculate the total detection rate of chromosomal polymorphisms in this population,the detection rate of chromosomal polymorphisms in different genders,and the distribution of various common polymorphism types.Secondly,the effect of pregenacy outcome in infertile couples treated with IVF/ICSIET were discussed by trying different grouping methods.Pregnancy-related laboratory indicators(fertilization rate,cleavage rate,excellent embryo rate)and clinical indicators(implantation rate,biochemical pregnancy rate,clinical pregnancy rate,premature delivery rate,continuous pregnancy rate,delivery rate,preterm birth rate,perinatal malformation rate)were involved.Result 1.The detection rate of chromosomal polymorphism in infertile patients was 3.93%,which was 2.2 times that of the normal population;2.The detection rate of male patients was higher than that of female patients(5.04%>2.81%).The most common type of polymorphism in male infertility patients is the D/G group,the most common karyotype is 1qh+/-and Y chromosome polymorphism;the most common type of polymorphism in female infertility patients is 1,9,and 16 chromosomes,and the most common karyotypes are inv(9)and 1qh+/-;3.The early abortion rate of chromosomal polymorphism group was significantly higher than that of normal chromosome group(23.29% vs 10.70%,P<0.05).4.There is no statistical difference in the effect of chromosome polymorphism of different genders on IVF/ICSI-ET pregnancy outcome in infertile patients.It may reduce fertilization rate and cleavage rate when the couples are both polymorphic.5.In comparison of different types of polymorphisms with normal chromosomes group,the rate of excellent embryos in 1,9 and 16 chromosome was significantly lower than that in the normal group(38.53% vs 42.83%,P<0.05).Conclusion 1.The detection rate of chromosomal polymorphism in infertile people is significantly higher than that in normal people,and males are higher than females.2.The distribution of chromosome polymorphisms on different genders is different.3.The incidence of early abortion in patients with chromosomal polymorphism is significantly higher than that of normal chromosomes,and it is statistically significant.4.Although there is no statistical difference in the analysis of other pregnancy-related indicators,there is a certain trend suggested that chromosome polymorphism may have certain clinical effects,and chromosome polymorphisms of different genders and different types may affect pregnancy outcomes in different aspects.Patients with chromosomal polymorphisms found in clinical work should be reminded to pay more attention to the production inspection. |
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