Methotrexate Combined Obstinate Arlhralgia Soup Treatment Of Rheumatoid Arthritis(Deficiency And Blood Stasis Resistance Type) Of Clinical Observation

Objective: observation of methotrexate combined with kidney and phlegm and eliminating stasis for experience formula of the principle of effective obstinate arlhralgia decoction for rheumatoid arthritis(ra) in patients with kidney deficiency and blood stasis resistance type efficacy and safety of application. Further explore the therapeutic principle of kidney and blood stasis resistance type rheumatoid arthritis treatment, for clinical provides the idea and method.Methods: based on randomized, parallel test principle, selection in conformity with the inclusion criteria of 60 patients with rheumatoid arthritis. Group therapy for methotrexate combined therapy of obstinate arlhralgia soup control to methotrexate therapy. Two groups of continuous medication for 12 weeks. Observation and record 0, 12 weeks, the patient’s clinical condition, including the number of joint swelling and pain, morning stiffness time, TCM symptoms integral, etc; Monitoring and routine blood, liver and kidney function, such as test projects, and record a variety of adverse reactions; Write down two sets of replacement consumption indicators. Choose developed by American society for rheumatism ACR20, 50, 70 and TCM symptoms curative effect evaluation standard for clinical therapeutic effect evaluation references.Results: the curative effect evaluation of disease: the observation group curative effect, ACR50 standard, ACR20 ACR70 standard standard 6, 18, 28 cases, respectively, it is concluded that the total effective rate was 96.7%. Control efficacy, ACR50 standard, ACR20 ACR70 standard standard of 2, 6, 17 cases respectively, it is concluded that the "meaningful" standard(P < 0.05). Symptom curative effect comparison: observation group of 30 cases, the number of patients with clinical cure, powerfully and effectively 3, 17, 9 cases respectively, and the invalid in 1 case, the total effective rate reached 96.7%, and control in patients accounted for 66.7%; Control group 30 cases, the number of patients with clinical cure, powerfully and effectively 1, 11, 9 cases respectively, and the invalid 9 cases, the total effective rate reached 70.0%, and control patients accounted for 40.0%. Based on statistical processing, the total effective rate of the two groups and the proportion of patients have obvious differences, "meaningful" standard(P < 0.05). TCM symptoms comparison: in the aspect of joint swelling pain, morning stiffness duration, based on statistical processing, obvious differences in both groups, "meaningful" standard(P < 0.05); Pain at night is aggravating group of drugs is better than that in control group, in improving the symptom of especially pain at night is aggravating and lumbar debility, curative effect is prominent. In the replacement index, VAS and security level, based on statistical processing, obvious differences in both groups, "meaningful" standard(P < 0.05). And the observation group compared the control group is optimal.Conclusion: for rheumatoid arthritis(ra) in patients with kidney deficiency and blood stasis phlegm obstruction, methotrexate combined the of obstinate arlhralgia soup results in various clinical observation projects, than methotrexate alone to good results. Clew kidney and phlegm and dispelling stasis method in the treatment of kidney and blood stasis resistance type has the feasibility of rheumatoid arthritis.