Study On The Medical Preparations Of Jueshui Xiaozhong Granules

OBJECTIVE:This study mainly decided to carry out Medical Preparation of Jueshui Xiaozhong Granules, includes preparation process, quality standard research, acute toxicity test and Study on the stability of preparation, Jueshui Xiaozhong Decoction in the treatment of primary clinical study of chronic glomerular nephritis with edema..METHODS AND RESULTS:1 Study on preparation technologyThe preparation process of the preparation process was determined by orthogonal test and formulation of the preparation technology: Take prescription of Poria cocos herbs, add appropriate amount of water soaked in permeabilized, Plantago another package, and the remaining 11 flavor together with 8 times amount of water is boiled 1.5 hours, were performed twice, out to remove dregs and liquid static take concentrated supernatant. The paste adding dextrin into 1000 g particles, whole grain drying after sealing plastic bags, into 10 grams / bag, namely.2 Study on quality standardWere thin layer chromatographic identification of Poria, Atractylodes macrocephala and tangerine peel. Results showed that three kinds of herbs by TLC spots was clear, no negative interference. The method is simple and feasible; duel of water swelling particles size, water solubility, load difference, hygiene, extract inspection, are in conformity with the provisions.3 Stability testJueshui Xiaozhong Granules with aluminum-plastic composite packaging film, were stored at room temperature for 12 months, 37 to 40℃, RH75% under the condition of stored six months, testing the indicators, the drug quality is stable. According to the results of the stability test, the effective date of no water swelling particles for 12 months.4 The acute toxicity testJueshui Xiaozhong Granules on acute toxicity test in mice, in clinical doses of 58 times the highest concentration of crude drugs,(1.89 g ?ml-1), the maximum volume(40ml?kg-1) to fill the stomach, 2 times a day, 14 days of observation, no toxic reaction,appear so this mouse lavage maximum tolerated dose greater than 151.2g?kg-1, safe and reliable.5 Clinical observationThrough clinical observation of 196 patients showed that the Jueshui Xiaozhong Granules, to the primary treatment of chronic glomerular nephritis with edema has remarkable curative effect, its effect is better than that of the control group; never Jueshui Xiaozhong Granules can improve clinical symptoms in patients with, its effect is better than that of the control group; never Jueshui Xiaozhong Granules can enough to reduce the red blood cells in the urine of patients with chronic glomerular nephritis edema, its effect is better than that of the control group; never Jueshui Xiaozhong Granules changes of blood uric acid in patients with edema is not obvious; Jueshui Xiaozhong decoction is effective and safe, without adverse reaction.CONCLUSION:The study showed that Jueshui Xiaozhong Granules through scientific and reasonable preparation, the quality standards, stability, safety, non-toxic side effects to improve the clinical symptoms in patients with chronic glomerular nephritis edema. Therefore, development Jueshui Xiaozhong Granules institution preparation to reduce and prevent further development of kidney disease has a important significance.