| Objective:Leflunomide(LEF) is one of the medicines commonly used to treat Rheumatoid arthritis(RA).However, it has bad effects on patients’ blood system and digestive system. Leucopenia is one of its toxic and adverse effects. The thesis studies how LEF works and controls RA patients’ condition by observing the numbers of the white blood cells in 3 months.Besides, it studies how cake-separated mild moxibustion controls the white cells after RA patients’ taking LEF by contrasting another treat method – only taking LEF,without cake-separated mild moxibustion. The contrast will show how cake-separated mild moxibustion increases the number of the white blood cells, and provide theoretical and experimental basis for the application of cake-separated mild moxibustion to the RA patients with Leucopenia caused by the immune control agent. Methods: 1. clinical data:RA patients from department of rheumatism in Wuhan hospital of traditional Chinese medicine from 2014,July to the following January. Choose 50 patients at random whose number of white blood cells was normal before taking LEF, and divided them into two groups according to the doctor order:one is treatment group: under the treatment of cake-separated mild moxibustion after taking LEF;another is control group :only taking LEF. Each group has 25 patients. 2.Treatment methods:control group:25 patients were given two pieces of LEF,(each piece in 10 mg),once a day,oral medication for 3months.treatment group: on the basic of the control group,25 patients were under treatment of cake-separated mild moxibustion,five times a week and lasted for 3 months.When one patient felt severely pain about his joint and cannot bear any more, he would take Loxoprofen Sodium Tablets in terms of his condition, three times a day, each times taking one piece(each piece is 60 mg). It was not a conventional treatment, and it stopped taking when it achieved remission of symptoms. In addition, not taking any other relevant traditional Chinese or Western medicines related to the disease itself. 3. Observing targets:Symptoms and physical sign index: morning stiffness time, rest pain, joint function, swollen joint count index, tender joint count, the average hands grip strength, VAS, patience evaluation, disease activity score, HAQ index, DAS28, etc;Radiographic signs of joint: mainly observing hands’ X-ray graphic.Laboratory index : rheumatoid factor, ESR, CRP, CCP, leukopenia count, neutrophil count.Adverse effects: gastrointestinal reaction, alopecia, skin rash, liver function damage, the change of blood system. 4. Statistical methods:Applying SPSS19.0 statistic software for statistical processing; measurement data using t for testing, count data using x2 for testing, level data using Ridit for testing, statistical indicators data expressed in x±s, when P<0.05 said the difference was statistically significant. Results:with the guidance of the doctor, two group patients ’ compliance were both good. No drug withdrawal by patients, or stopping the treatment of cake-separated mild moxibustion. No such cases as falling off, eliminating during the treatment. 1. After three months treatment, the control group ’ s total effective rate was 84%, while the treatment group ’s was 96%, which shows the difference was statistically significant(P<0.05). Therefore, the treatment group was better than the control group. 2. Before the treatment, two groups’ joint imaging statistical analysis does not exist significant differences(P>0.05). After the treatment,there is still no significant differences between the two groups ’ joint imaging statistical analysis, even in each of the group(P<0.05). 3. Before the treatment, the comparison of two groups’ data about RF,ESR and CPR show no significant differences between each other(P>0.05).However, after the treatment, when compare the data again, there is significant differences between two groups,even in each of the group(P<0.05),which shows that LEF plays an important role in controlling RA’s laboratory indexes and the treatment group is better than that of the control group. 4. Before the treatment, the numeration of leukocyte and the neutrophil count of the two groups have no statistically significant difference(P<0.05). They are comparable. But after the treatment, by comparing the numeration of leukocyte and the neutrophil count of the two groups, statistical analysis showed that the difference was statistically significant(P<0.05).By comparing the data before and after the treatment of the treatment group, statistical analysis showed no significant differences. The study showed that one of the side effects were leucopenia and neutropenia when using LEF to treat Rheumatoid arthritis. However, with the treatment of cake-separated mild moxibustion at the same time to treat Rheumatoidarthritis, the occurrence of the side effect can be reduced. Conclusion:The curative effect of taking LEF and under the treatment of cake-separated mild moxibustion is obviously better than the treatment of only taking LEF. At the same time, the treatment of cake-separated mild moxibustion can effectively control leucopenia and neutropenia caused by LEF during the treatment. |
PDF Full Text Request