The Theory Of Body Fluid’s Metabolism And Its Clinical Research In The Active Rheumatoid Arthritis

In the clinical practice we found that almost all patients with active rheumatoid arthritis had joint swelling in different degrees, or even effusion.My teacher with rich clinical experience pointed out that the water and dampness was the main pathological factors. The exogenous dampness and endogenous dampness causes by the disorder of body fluid’s metabolism emptied into the joints and blocked the main and collateral channels.So, we deeply analyzed the theory of body fluid’s metabolism,and found that it’s distribution, operation and excretion depends on transfer of spleen, dispersing and descending of lung, regulation of kidney and gasification function of sanjiao.In the active stage of the rheumatoid arthritis,the lack of power caused by the debility of Qi,the disorder of transfer caused by poor diet, dysfunction of Qi caused by emotional disorders, the imbalance of yin and Yang caused by the deficiency of the kidney,etc,all these could lead to the disorder of body fluid’s metabolism. In addition, the clinical symptoms of the most patients had in the active RA was redness, touch the fever of the joint.So, We believed that the dampness was an important pathology factor of active RA, damp heat toxin blocking main and collateral channels was the basic pathogenesis.In clinical practice, according to the etiology and pathogenesis mentioned in the above,we formulated the treatment principle of chushi tongluo,qingre jiedu. And we developed chushi jiedu soup as the basic prescription to treat the active rheumatoid arthritis.In the reash,the 58 patients we choiced were devided into two groups: the observation group and the control group. The observation group was given chushi jiedu soup and MTX. The control group was only given MTX.After 3 months later,we evaluated the treatmeng effect and the activity of the disease by the ACR standard and DAS-28(4). Statistical analysis showed: in the observation group there were 2 cases reached the standard of ACR70,11 cases reached the standard of ACR50,14 cases reached the standardof ACR20,the total effective rate was 93.10 percect;in the control group, there were 1 cases reached the standard of ACR70,3 cases reached the standard of ACR50,146 cases reached the standard of ACR20,the total effective rate was 69.97 percect;the observation group was better than that of the control group(P<0.05). In reducing disease activity score after treating,the DAS28(4)scores of the observation group were reduced(2.30±0.95);and the DAS28(4)scores of the control group were reduced(1.49±0.76); the observation group was obviously better than that of the control group(P<0.01). In the aspect of TCM syndrome curative effect, in the observation group there were 2 cases achieved the clinical controlling,5 cases achieved marked effect,and effective in 20 cases,the total effective rate was 93.10 percect; in the control group there were 0 cases achieved the clinical controlling,2 cases achieved marked effect,and effective in 17 cases,the total effective rate was 70.37 percect; the observation group was better than that of the control group(P<0.05). In addition, in the aspect of improving joint function, observation group is better than that of control group(P < 0.05).The curative effect of chushi jiedt soup was objective in the treatment of active rheumatoid arthritis.