Research On Yishen Tocolysis Side Effect On The Treatment Of Early Threatened Abortion

Objective:The author respectively by Chinese and western medicine and Chinese medicine treatment of threatened abortion patients(Before 12 weeks gestational age) during treatment. By observing the patient’s general condition, symptom integral, clinical efficacy, embryo forming rate, serum E2, P, β-HCG value and other indicators, to observe the curative effect of traditional Chinese medicine decoction on the early threatened abortion, and to analyze its mechanism. Use of traditional Chinese medicine treatment of artificial rats model of kidney empty abortion type, monitoring the general situation, miscarriage rate and T helper cells, analyzes the effect of Chinese medicine spuc system.Methods:Clinical study, the author USES the retrospective analysis method, the choice of jiangsu province hospital outpatients of department of gynaecology, Time from January 2014 to December 2014, Diagnosis in early threatened abortion, TCM syndrome type of kidney deficiency type, a total of 60 cases. Randomly divided into two groups, the western medicine group,30 cases, oral flexor progesterone (duff tong), intramuscular progesterone injection.Chinese and western medicine group,30 cases, at the same time of using western medicine treatment increased kidney fetus Chinese medicine decoction treatment. Treatment in the process of monitoring the serum estradiol (E2) and progesterone (P), beta villi gonadotropin (beta HCG) value, and pelvic ultrasound. Experiment study, the use of SPF SD rats, the number to 24, using hydroxyl urea+make kidney empty mifepristone abortion model rat, After building were randomly divided into 3 groups, group A with kidney fetus Chinese medicine decoction lavage, referred to as Chinese traditional medicine group;Group B with physiological saline lavage, called kidney abortion group.Group C using progesterone injection intramuscular injection, known as the western medicine group. Monitoring serum levels of T helper cells (Th), the experiment selected monitoring of Thl (IFN-gamma, IL-2) and Th2 (IL-4, IL-10) two kinds of factors, from the perspective of immunology study spuc mechanism of traditional Chinese medicine decoction.Results:the clinical study, after active treatment, two groups of patients with syndrome of TCM can be effectively improved; 50 days of pregnancy, Chinese and western medicine treatment group patients serum E2, P, a-HCG value with western medicine treatment group had obvious difference (P<0.05) in curative effect, the western medicine group was less than the Chinese and western medicine treatment group; Pregnancy day 70, two groups of patients only serum E2, P values have obvious difference (P<0.05), the curative effect on Chinese and western medicine better than western medicine group;Chinese and western medicine treatment group patients with fetal forming rate is higher. Experiment study, the DO days, between the three groups, comparable.D9 days, there was no significant difference between group A and group C (P>0.05), group A and group CIL-2, IFN-Y, IL-4, IL-10, compared with group B were significantly different (P<0.05), and thus concluded that renal fetus party on rat kidney abortion in serum IL-2/IL-4 have adjustment function, its role and progesterone.Conclusion:curative effect is superior to pure western medicine the progesterone, combination of Chinese and western treatment of the patient’s level of progesterone growth faster, curative effect is more apparent, eventually forming the fetus rate is also higher.Chinese medicine kidney fetus in immune, can reduce the Thl level, improve the level of Th2, adjust the balance of Thl and Th2, Treatment with progesterone injection, maybe that’s one of the mechanism of the traditional Chinese medicine treatment of early threatened abortion.