Correlation Analysis Of Risk Factors Of Mammary Atypical Hyperplasia And Breast Cancer

Breast cancer was one of the most common malignant tumor that threating women’s health and life. Although etiology of breast cancer is still not clear, a well-known recognizeation is "multi-stage development model theory", which developed from normal to general hyperplasia, atypical hyperplasia, carcinoma in situ and infiltrating carcinoma, under the influences of some risk factors. Having been influencing by some risk factors, experienced quantitative and qualitative change, precancerous atypical hyperplasia finally transformed into malignant tumor; in the opposite case, if the risk factors were cleared away, the lesion could be stable or reversed. So the intervention treatment focusing on precancerous atypical hyperplasia may effectively reduce the incidence of breast cancer. It is necessary to research the risks as well as related detail mechanism to reduce the incidence of breast cancer. A large number of studies have shown that there is a significant relation between reduce breast cancer mortality and a large number of early carcinoma diagnosed by screening, Under early diagnosis, timely and correct treatment, majority of patients can survive for a long time, even cure. Not only appropriate treatment but also early diagnosis is helpful to effectively improve breast cancer survival rates and reduce the absolute mortality. Improving the breast cancer risk prediction and early diagnosis are keys to the prevention and treatment. Most of the large sample researches were aimed to explore the risk factors related to breast cancer, especially in the exposure intensity and stimulating intensity. However, the correlation study of mammary atypical hyperplasia and breast cancer are very little. Therefore, our study focus on correlation risk factors between breast atypical hyperplasia and breast cancer.Purpose:According to the general situation of certain people, such as:age, menstrual related factors, frequency of abortion, the number of live births, and history of alcohol and tobacco, high body mass index, and family history of malignancy, explore risk factors of breast atypical hyperplasia and breast cancer, and further find mammary atypical hyperplasia risk factors playing a key role in the process of progress to breast cancer, and to provide basis for early diagnosis and prevention of breast cancer.Selection methods:111 patients with mammary atypical hyperplasia and 156 patients with primary breast cancer were enrolled respectively from January 2013 to October 2014 demographic, clinical and conventional analytical variables were documented. Logistic regression analyses were performed to determine the relationship between mammary atypical hyperplasia related risk factors and breast cancer related risk factors. Statistical analyses were done using SPSS statistical software, version 19.0.Results:Age, menarche, menopause and abortion are significantly related risk factors between mammary atypical hyperplasia and breast cancer, especially the age, menopause and abortion times.Conclusion:Age, menarche, menopause and abortion are significantly related risk factors between mammary atypical hyperplasia and breast cancer to prevention should be taken with a targetedsexual comprehensive measures.