Clinical Research On Liver Resection After Application Of Xuebijing

Primary liver cancer is one of the common malignant tumors in our country, but also the quantity is still one of the few rise in malignant tumor, The mortality rate of HCC in China for20.4/100000, About half of the entire world liver cancer deaths, ranking the mortality of malignant tumor in second, its difficult to treat is a malignant tumor of the first, and liver resection operation remains the preferred method for the treatment of liver cancer,But after hepatic resection, infection, hemorrhage, biliary leakage, abnormal liver function and other complications affect postoperative recovery, excessive inflammatory reaction after operation,IL-1、IL-6 and TNF-a are proinflammatory cytokines important, the interaction between the formation of many positive feedback loop ", resulting in inflammation cascade reaction", make the inflammation aggravate, destroy the remnant liver.Liver resection operation on liver function damage and even the cause of hepatic failure, mortality is still high, so the prevention of patients with postoperative infection, promote liver function recovery has become the focus of clinical work. After conventional anti infection, nutritional support and treatment of liver, patients can be discharged smoothly,After conventional anti infection, nutritional support and treatment of liver, patients can be discharged smoothly,But the postoperative complication of severe infection, hepatic failure patients hospitalization time and costs increased significantly.Chinese medicine in Qingrejiedu, enhance physical fitness has obvious advantages.But the Xuebijing in hepatectomy field especially for the restoration of liver function after operation little,The purpose of this study was to the clinical curative effect on liver resection operation patients through clinical research study of Xuebijing injection application,Especially the effect on liver function and inflammatory factors changes, to further clarify the clinical curative effect, provides the basis for the treatment of liver resection.Objective:Through randomized controlled clinical trials, to observe the clinical curative effect of Xuebijing injection applied to liver resection operation patients,Especially the effect on liver function and inflammatory factors changes, to further clarify the clinical curative effect, provides the basis for the treatment of liver resection.Method:The test in 2014 January to 2015 January in the 81 Hospital of PLA,60 cases of surgical tumor resection as the observation object.In the conventional treatment of anti infection, nutritional support in 20 cases as the blank group, on the basis of conventional treatment combined with ulinastatin,In the day after the use of ulinastatin (2 20wiu/day) intravenously for 5 days in 20 cases as control group, on the basis of conventional treatment with Xuebijing injection,On postoperative day 50ml Xuebijing injection (2/day) intravenously for 5 days in 20 cases as experimental group.The 3 groups before operation and on postoperative day seventh to do Indocyanine green test.And on the first day, after third days, seventh days respectively blood blood routine examination:White blood cell count, neutrophil count;Liver function:Total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, albumin;Inflammatory factor:IL-1,IL-6 and TNF-a.and then Statistical analysis.Results:The experimental observation and comparison, liver resection in patients with peri operation period of WBC, N, in the blank group, control group, treatment group were compared between the three groups, the treatment group after third days was better than the control group, the treatment group, the control group had no significant difference between the patients with peri operation period; TBIL, DBIL, ALT, AST, ALB showed no significant difference between the three groups of patients in peri operation period; the ALB between the three groups, treatment group, postoperative ALB recovery was significantly better than the control group, the treatment group and the control group the differences on the third postoperative day, there was no difference in seventh days after operation; peri operation period of IL-1 in the three groups compared with the blank group, control group and treatment group increased significantly, but on the third day after operation decreased to seventh days, and the control group, the treatment group tended to be the same. Patients in the peri operation period, TNF-a in the three groups reached the peak on the third postoperative day, and the treatment group was significantly decreased in the seventh day. Patients in the peri operation period, compared with IL-6 in the three groups, the treatment group on the first postoperative day was significantly higher than the control group, the treatment group and the control group had no significant difference, after third days, three groups reached the peak, but the treatment group than in the other two groups significantly increased, seventh, the treatment group and the the blank group, the control group decreased significantly compared.Conclusion:The process of Xuebijing injection in postoperative early IL-6, inhibit the release of IL-1, TNF-alpha release, reduce the inflammatory cascade reaction, reduce the liver cell membrane damage, at the same time, IL-6 can promote the release of proteolytic enzymes, remaining in the liver is activated, the liver cells in the liver tissue by remaining resting activation, the regeneration of liver cells, promote the recovery of liver function of the patients after the operation in patients with liver failure, prevent complications, reduce the mortality of liver resection during operation period.