| Background:Esophageal cancer is one of common digestive tract.Chemotherapy is the main way to treat advanced esophageal cancer presently,but efficacy is poor overall because most patients Interrupt the treatment for the toxicity of chemotherapy.Objective:This study was designed to compare the clinical efficacy of YeGe-1-Prescription on by combined chemotherapy and chemotherapy,and clinical efficacy in improving the quality of life of patients, improve patient tolerance, reduce the toxicity of chemotherapy and other aspects.Method:According to the diagnostic criteria of esophageal cancer, TCM diagnostic criteria, "Chinese common malignancy norms" and other standards to select out of 60 patients randomly.They will be divided into treatment group (Co-righting cancer chemotherapy:PTX 135-175mg/m2 iv dl, DDP 80-100mg/m2 iv dl) and control group (chemotherapy), and give them more than two cycles of treatment.And add up the clinical symptoms observed in patients before and after treatment, the physical including aspects of the state, quality of life, tumor-related indicators, such as chemotherapy toxicity, and compare the efficacy.Results:There are significant differences (P<0.05) between the results of the treatment group and the control group in terms of traditional Chinese medicine syndrome,which suggesting that the treatment group than the control group. Two groups of patients before treatment was no significant difference (P> 0.05) in part of quality of life, physical condition and weight,while the two groups were statistically significant (P<0.05) after treatment. There was no difference between the two groups of patients was statistically significant (P> 0.05) before and after the treatment in improving their diet. In terms of side effects of chemotherapy, the treatment group has statistically significant (P<0.05) in white blood cells, thrombocytopenia, bone marrow suppression, gastrointestinal reactions. The difference was not statistically significant (P> 0.05) in anemia, liver and kidney function, allergies, neurotoxicity.Two groups of patients before treatment difference was not statistically significant indicators (P> 0.05) in CEA,while two groups of patients after treatment index difference was statistically significant (P<0.05). Treatment group difference between the results before and after treatment there was statistically significant (P<0.05) in CEA. The results of the control group before and after treatment showed no significant difference (P> 0.05) in CEA. The two groups of patients before treatment difference was not statistically significant indicators (P> 0.05) in CA199. The two groups after treatment was statistically significant indicators (P<0.05).Differences between the treatment and control groups before and after comparison of the differences were statistically significant indicators (P<0.01) before and after treatment.Conclusion:1.YeGe-1-Prescription helps patients with advanced esophageal cancer in aspects of clinical symptoms, physical condition, quality of life, weight, diet and other aspects of the situation.2.YeGe-1-Prescription has been effective in reducing the side effects of chemotherapy portion of the control tumor markers. It is worth to be spreaded. |
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